DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons

DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons

Epigenetic mechanisms are emerging key players for the regulation of brain function, synaptic activity, and the formation of neuronal engrams in health and disease. As one important epigenetic mechanism of transcriptional control, DNA methylation was reported to distinctively modulate synaptic activ...

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Bibliographic Details
Main Authors: Sarah Bachmann, Jenice Linde, Michael Bell, Marc Spehr, Hans Zempel, Geraldine Zimmer-Bensch
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
DNMT1
human iPSC
layer 2/3 cortical neurons
synaptic activity
spontaneous activity
calcium imaging
Online Access:https://www.mdpi.com/1422-0067/22/4/2034

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