SIRT6 in Senescence and Aging-Related Cardiovascular Diseases
SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases and has established diverse roles in aging, metabolism and disease. Its function is similar to the Silent Information Regulator 2 (SIR2), which prolongs lifespan and regulates genomic stability, telomere integrity,...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-03-01
|
Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.641315/full |
id |
doaj-4dc7f76b552f4bc5b245bab3a34dccdc |
---|---|
record_format |
Article |
spelling |
doaj-4dc7f76b552f4bc5b245bab3a34dccdc2021-03-29T05:33:47ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.641315641315SIRT6 in Senescence and Aging-Related Cardiovascular DiseasesXiaokang Li0Lin Liu1Tian Li2Manling Liu3Yishi Wang4Heng Ma5Nan Mu6Haiyan Wang7Department of Cardiology, China Tangdu Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Dermatology, Tangdu Hospital, Fourth Military Medical University, Xi’an, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaDepartment of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, ChinaDepartment of Cardiology, China Tangdu Hospital, Fourth Military Medical University, Xi’an, ChinaSIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases and has established diverse roles in aging, metabolism and disease. Its function is similar to the Silent Information Regulator 2 (SIR2), which prolongs lifespan and regulates genomic stability, telomere integrity, transcription, and DNA repair. It has been demonstrated that increasing the sirtuin level through genetic manipulation extends the lifespan of yeast, nematodes and flies. Deficiency of SIRT6 induces chronic inflammation, autophagy disorder and telomere instability. Also, these cellular processes can lead to the occurrence and progression of cardiovascular diseases (CVDs), such as atherosclerosis, hypertrophic cardiomyopathy and heart failure. Herein, we discuss the implications of SIRT6 regulates multiple cellular processes in cell senescence and aging-related CVDs, and we summarize clinical application of SIRT6 agonists and possible therapeutic interventions in aging-related CVDs.https://www.frontiersin.org/articles/10.3389/fcell.2021.641315/fullSIRT6senescencecardiovascular diseasesautophagyoxidative stress |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiaokang Li Lin Liu Tian Li Manling Liu Yishi Wang Heng Ma Nan Mu Haiyan Wang |
spellingShingle |
Xiaokang Li Lin Liu Tian Li Manling Liu Yishi Wang Heng Ma Nan Mu Haiyan Wang SIRT6 in Senescence and Aging-Related Cardiovascular Diseases Frontiers in Cell and Developmental Biology SIRT6 senescence cardiovascular diseases autophagy oxidative stress |
author_facet |
Xiaokang Li Lin Liu Tian Li Manling Liu Yishi Wang Heng Ma Nan Mu Haiyan Wang |
author_sort |
Xiaokang Li |
title |
SIRT6 in Senescence and Aging-Related Cardiovascular Diseases |
title_short |
SIRT6 in Senescence and Aging-Related Cardiovascular Diseases |
title_full |
SIRT6 in Senescence and Aging-Related Cardiovascular Diseases |
title_fullStr |
SIRT6 in Senescence and Aging-Related Cardiovascular Diseases |
title_full_unstemmed |
SIRT6 in Senescence and Aging-Related Cardiovascular Diseases |
title_sort |
sirt6 in senescence and aging-related cardiovascular diseases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2021-03-01 |
description |
SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases and has established diverse roles in aging, metabolism and disease. Its function is similar to the Silent Information Regulator 2 (SIR2), which prolongs lifespan and regulates genomic stability, telomere integrity, transcription, and DNA repair. It has been demonstrated that increasing the sirtuin level through genetic manipulation extends the lifespan of yeast, nematodes and flies. Deficiency of SIRT6 induces chronic inflammation, autophagy disorder and telomere instability. Also, these cellular processes can lead to the occurrence and progression of cardiovascular diseases (CVDs), such as atherosclerosis, hypertrophic cardiomyopathy and heart failure. Herein, we discuss the implications of SIRT6 regulates multiple cellular processes in cell senescence and aging-related CVDs, and we summarize clinical application of SIRT6 agonists and possible therapeutic interventions in aging-related CVDs. |
topic |
SIRT6 senescence cardiovascular diseases autophagy oxidative stress |
url |
https://www.frontiersin.org/articles/10.3389/fcell.2021.641315/full |
work_keys_str_mv |
AT xiaokangli sirt6insenescenceandagingrelatedcardiovasculardiseases AT linliu sirt6insenescenceandagingrelatedcardiovasculardiseases AT tianli sirt6insenescenceandagingrelatedcardiovasculardiseases AT manlingliu sirt6insenescenceandagingrelatedcardiovasculardiseases AT yishiwang sirt6insenescenceandagingrelatedcardiovasculardiseases AT hengma sirt6insenescenceandagingrelatedcardiovasculardiseases AT nanmu sirt6insenescenceandagingrelatedcardiovasculardiseases AT haiyanwang sirt6insenescenceandagingrelatedcardiovasculardiseases |
_version_ |
1724199059389939712 |