La determinación del hierro en el citrato de hierro amoniacal y en jarabes que lo contienen

• Main Authors: Luis Enrique Gaviria Salazar, Antonio Otálora
• Format: Article
• Language: English
• Published: Universidad Nacional de Colombia 1963-01-01
• Series: Revista de la Facultad de Medicina
• Subjects: hierro; análisis químico; farmacopeas; método complexométrico
• Online Access: https://revistas.unal.edu.co/index.php/revfacmed/article/view/22561
• ISSN: 0120-0011; 2357-3848

A comparative study was made of three methods for the determination of iron in ferric ammonium citrates and in syrups containing this compound. The methods selected were the folowing: 1. Complexometric method with EDTA, ethylenediamine tetra-acetic acid sodium salt. 2. U. S. pharmacopeia method. 3. British pharmacopeia method. Conclusions in the evaluation of each method: The complexometric method with EDTA cannot be applied in this case, since it gives very low results due to two interferences: the impossibility of cstablishing the end-point in titration and only partial dissolution of the iron complex when the solution is mixed with hydrochloric acid before titration. In each assay therefore one determines only a part, major on minor, of iron, in accordance with the conditions under wich one works. The U. S. pharmacopeia method is useful to determine the iron content in the ferric ammonium citrate established by the same pharmacopeia and whose iron content is within the following limits: 16.5 and 18.5 per cent. However, for citrates and syrups with a larger amount of iron, the method is not applicable. This is due to the medium solution used as it lacks sufficient acidity to dissolve completely the iron complex. The Bristish pharmacopeia method is recommended because due to its more acid medium it always gives consistent results with any ferric ammonium citrate tested. For syrups containing this citrate this method with the modifications suggested is also recommended.