A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion
From single-cell transcriptome analyses to defining culture media for spheroids, the authors provide a census of information to understand the development of human pancreatic progenitors. This approach identifies signalling pathways (EGF and FGF) regulating progenitor proliferation.
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| Language: | English |
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Nature Publishing Group
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23295-6 |
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doaj-4dd4448416d0483cbbb89a084390dda12021-05-30T11:15:03ZengNature Publishing GroupNature Communications2041-17232021-05-0112111710.1038/s41467-021-23295-6A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansionCarla A. Gonçalves0Michael Larsen1Sascha Jung2Johannes Stratmann3Akiko Nakamura4Marit Leuschner5Lena Hersemann6Rashmiparvathi Keshara7Signe Perlman8Lene Lundvall9Lea Langhoff Thuesen10Kristine Juul Hare11Ido Amit12Anne Jørgensen13Yung Hae Kim14Antonio del Sol15Anne Grapin-Botton16The Novo Nordisk Foundation Center for Stem Cell BiologyThe Novo Nordisk Foundation Center for Stem Cell BiologyCIC bioGUNE-BRTA (Basque Research and Technology Alliance)Max Planck Institute of Molecular Cell Biology and GeneticsThe Novo Nordisk Foundation Center for Stem Cell BiologyMax Planck Institute of Molecular Cell Biology and GeneticsMax Planck Institute of Molecular Cell Biology and GeneticsMax Planck Institute of Molecular Cell Biology and GeneticsDepartment of Gynaecology, University Hospital of Copenhagen (Rigshospitalet)Department of Gynaecology, University Hospital of Copenhagen (Rigshospitalet)Department of Obstetrics and Gynaecology, Hvidovre University HospitalDepartment of Obstetrics and Gynaecology, Hvidovre University HospitalThe Weizmann instituteDepartment of Growth and Reproduction, Copenhagen University Hospital (Righshospitalet)Max Planck Institute of Molecular Cell Biology and GeneticsCIC bioGUNE-BRTA (Basque Research and Technology Alliance)The Novo Nordisk Foundation Center for Stem Cell BiologyFrom single-cell transcriptome analyses to defining culture media for spheroids, the authors provide a census of information to understand the development of human pancreatic progenitors. This approach identifies signalling pathways (EGF and FGF) regulating progenitor proliferation.https://doi.org/10.1038/s41467-021-23295-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Carla A. Gonçalves Michael Larsen Sascha Jung Johannes Stratmann Akiko Nakamura Marit Leuschner Lena Hersemann Rashmiparvathi Keshara Signe Perlman Lene Lundvall Lea Langhoff Thuesen Kristine Juul Hare Ido Amit Anne Jørgensen Yung Hae Kim Antonio del Sol Anne Grapin-Botton |
| spellingShingle |
Carla A. Gonçalves Michael Larsen Sascha Jung Johannes Stratmann Akiko Nakamura Marit Leuschner Lena Hersemann Rashmiparvathi Keshara Signe Perlman Lene Lundvall Lea Langhoff Thuesen Kristine Juul Hare Ido Amit Anne Jørgensen Yung Hae Kim Antonio del Sol Anne Grapin-Botton A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion Nature Communications |
| author_facet |
Carla A. Gonçalves Michael Larsen Sascha Jung Johannes Stratmann Akiko Nakamura Marit Leuschner Lena Hersemann Rashmiparvathi Keshara Signe Perlman Lene Lundvall Lea Langhoff Thuesen Kristine Juul Hare Ido Amit Anne Jørgensen Yung Hae Kim Antonio del Sol Anne Grapin-Botton |
| author_sort |
Carla A. Gonçalves |
| title |
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| title_short |
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| title_full |
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| title_fullStr |
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| title_full_unstemmed |
A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| title_sort |
3d system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-05-01 |
| description |
From single-cell transcriptome analyses to defining culture media for spheroids, the authors provide a census of information to understand the development of human pancreatic progenitors. This approach identifies signalling pathways (EGF and FGF) regulating progenitor proliferation. |
| url |
https://doi.org/10.1038/s41467-021-23295-6 |
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