Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.
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2020-11-01
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Online Access: | https://doi.org/10.1038/s41467-020-19473-7 |
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doaj-4dd529924c75463b9ab9f71c074acad62021-05-11T08:09:55ZengNature Publishing GroupNature Communications2041-17232020-11-0111111110.1038/s41467-020-19473-7Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s diseaseKevin Huynh0Wei Ling Florence Lim1Corey Giles2Kaushala S. Jayawardana3Agus Salim4Natalie A. Mellett5Adam Alexander T. Smith6Gavriel Olshansky7Brian G. Drew8Pratishtha Chatterjee9Ian Martins10Simon M. Laws11Ashley I. Bush12Christopher C. Rowe13Victor L. Villemagne14David Ames15Colin L. Masters16Matthias Arnold17Kwangsik Nho18Andrew J. Saykin19Rebecca Baillie20Xianlin Han21Rima Kaddurah-Daouk22Ralph N. Martins23Peter J. Meikle24Baker Heart and Diabetes InstituteSchool of Medical and Health Sciences, Edith Cowan UniversityBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteSchool of Medical and Health Sciences, Edith Cowan UniversitySchool of Medical and Health Sciences, Edith Cowan UniversitySchool of Medical and Health Sciences, Edith Cowan UniversityThe Florey Department of Neuroscience and Mental Health, The University of MelbourneThe Florey Department of Neuroscience and Mental Health, The University of MelbourneDepartment of Nuclear Medicine and Centre for PET, Austin HealthNational Ageing Research InstituteThe Florey Department of Neuroscience and Mental Health, The University of MelbourneDepartment of Psychiatry and Behavioral Sciences, Duke UniversityDepartment of Radiology and Imaging Sciences, Indiana University School of MedicineDepartment of Radiology and Imaging Sciences, Indiana University School of MedicineRosa & Co LLCBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San AntonioDepartment of Psychiatry and Behavioral Sciences, Duke UniversitySchool of Medical and Health Sciences, Edith Cowan UniversityBaker Heart and Diabetes InstituteThe onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.https://doi.org/10.1038/s41467-020-19473-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kevin Huynh Wei Ling Florence Lim Corey Giles Kaushala S. Jayawardana Agus Salim Natalie A. Mellett Adam Alexander T. Smith Gavriel Olshansky Brian G. Drew Pratishtha Chatterjee Ian Martins Simon M. Laws Ashley I. Bush Christopher C. Rowe Victor L. Villemagne David Ames Colin L. Masters Matthias Arnold Kwangsik Nho Andrew J. Saykin Rebecca Baillie Xianlin Han Rima Kaddurah-Daouk Ralph N. Martins Peter J. Meikle |
spellingShingle |
Kevin Huynh Wei Ling Florence Lim Corey Giles Kaushala S. Jayawardana Agus Salim Natalie A. Mellett Adam Alexander T. Smith Gavriel Olshansky Brian G. Drew Pratishtha Chatterjee Ian Martins Simon M. Laws Ashley I. Bush Christopher C. Rowe Victor L. Villemagne David Ames Colin L. Masters Matthias Arnold Kwangsik Nho Andrew J. Saykin Rebecca Baillie Xianlin Han Rima Kaddurah-Daouk Ralph N. Martins Peter J. Meikle Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease Nature Communications |
author_facet |
Kevin Huynh Wei Ling Florence Lim Corey Giles Kaushala S. Jayawardana Agus Salim Natalie A. Mellett Adam Alexander T. Smith Gavriel Olshansky Brian G. Drew Pratishtha Chatterjee Ian Martins Simon M. Laws Ashley I. Bush Christopher C. Rowe Victor L. Villemagne David Ames Colin L. Masters Matthias Arnold Kwangsik Nho Andrew J. Saykin Rebecca Baillie Xianlin Han Rima Kaddurah-Daouk Ralph N. Martins Peter J. Meikle |
author_sort |
Kevin Huynh |
title |
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease |
title_short |
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease |
title_full |
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease |
title_fullStr |
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease |
title_full_unstemmed |
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease |
title_sort |
concordant peripheral lipidome signatures in two large clinical studies of alzheimer’s disease |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-11-01 |
description |
The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD. |
url |
https://doi.org/10.1038/s41467-020-19473-7 |
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