Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease

The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.

Bibliographic Details
Main Authors: Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S. Jayawardana, Agus Salim, Natalie A. Mellett, Adam Alexander T. Smith, Gavriel Olshansky, Brian G. Drew, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Matthias Arnold, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, Peter J. Meikle
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19473-7
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spelling doaj-4dd529924c75463b9ab9f71c074acad62021-05-11T08:09:55ZengNature Publishing GroupNature Communications2041-17232020-11-0111111110.1038/s41467-020-19473-7Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s diseaseKevin Huynh0Wei Ling Florence Lim1Corey Giles2Kaushala S. Jayawardana3Agus Salim4Natalie A. Mellett5Adam Alexander T. Smith6Gavriel Olshansky7Brian G. Drew8Pratishtha Chatterjee9Ian Martins10Simon M. Laws11Ashley I. Bush12Christopher C. Rowe13Victor L. Villemagne14David Ames15Colin L. Masters16Matthias Arnold17Kwangsik Nho18Andrew J. Saykin19Rebecca Baillie20Xianlin Han21Rima Kaddurah-Daouk22Ralph N. Martins23Peter J. Meikle24Baker Heart and Diabetes InstituteSchool of Medical and Health Sciences, Edith Cowan UniversityBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteBaker Heart and Diabetes InstituteSchool of Medical and Health Sciences, Edith Cowan UniversitySchool of Medical and Health Sciences, Edith Cowan UniversitySchool of Medical and Health Sciences, Edith Cowan UniversityThe Florey Department of Neuroscience and Mental Health, The University of MelbourneThe Florey Department of Neuroscience and Mental Health, The University of MelbourneDepartment of Nuclear Medicine and Centre for PET, Austin HealthNational Ageing Research InstituteThe Florey Department of Neuroscience and Mental Health, The University of MelbourneDepartment of Psychiatry and Behavioral Sciences, Duke UniversityDepartment of Radiology and Imaging Sciences, Indiana University School of MedicineDepartment of Radiology and Imaging Sciences, Indiana University School of MedicineRosa & Co LLCBarshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San AntonioDepartment of Psychiatry and Behavioral Sciences, Duke UniversitySchool of Medical and Health Sciences, Edith Cowan UniversityBaker Heart and Diabetes InstituteThe onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.https://doi.org/10.1038/s41467-020-19473-7
collection DOAJ
language English
format Article
sources DOAJ
author Kevin Huynh
Wei Ling Florence Lim
Corey Giles
Kaushala S. Jayawardana
Agus Salim
Natalie A. Mellett
Adam Alexander T. Smith
Gavriel Olshansky
Brian G. Drew
Pratishtha Chatterjee
Ian Martins
Simon M. Laws
Ashley I. Bush
Christopher C. Rowe
Victor L. Villemagne
David Ames
Colin L. Masters
Matthias Arnold
Kwangsik Nho
Andrew J. Saykin
Rebecca Baillie
Xianlin Han
Rima Kaddurah-Daouk
Ralph N. Martins
Peter J. Meikle
spellingShingle Kevin Huynh
Wei Ling Florence Lim
Corey Giles
Kaushala S. Jayawardana
Agus Salim
Natalie A. Mellett
Adam Alexander T. Smith
Gavriel Olshansky
Brian G. Drew
Pratishtha Chatterjee
Ian Martins
Simon M. Laws
Ashley I. Bush
Christopher C. Rowe
Victor L. Villemagne
David Ames
Colin L. Masters
Matthias Arnold
Kwangsik Nho
Andrew J. Saykin
Rebecca Baillie
Xianlin Han
Rima Kaddurah-Daouk
Ralph N. Martins
Peter J. Meikle
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
Nature Communications
author_facet Kevin Huynh
Wei Ling Florence Lim
Corey Giles
Kaushala S. Jayawardana
Agus Salim
Natalie A. Mellett
Adam Alexander T. Smith
Gavriel Olshansky
Brian G. Drew
Pratishtha Chatterjee
Ian Martins
Simon M. Laws
Ashley I. Bush
Christopher C. Rowe
Victor L. Villemagne
David Ames
Colin L. Masters
Matthias Arnold
Kwangsik Nho
Andrew J. Saykin
Rebecca Baillie
Xianlin Han
Rima Kaddurah-Daouk
Ralph N. Martins
Peter J. Meikle
author_sort Kevin Huynh
title Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
title_short Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
title_full Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
title_fullStr Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
title_full_unstemmed Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
title_sort concordant peripheral lipidome signatures in two large clinical studies of alzheimer’s disease
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.
url https://doi.org/10.1038/s41467-020-19473-7
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