Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone
Cytogenetic analyses were performed on a bone giant cell reparative granuloma (GCRG) and on three bone giant cell tumors (GCT). The present GCRG case is the second to be described cytogenetically. A modal chromosome number of 46 was observed in all samples. Clonal chromosome abnormalities were detec...
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Sociedade Brasileira de Genética
2002-01-01
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| Series: | Genetics and Molecular Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000300002 |
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Article |
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doaj-4dd82b701cff45518397a11924b5be462020-11-25T01:54:21ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852002-01-0125326527010.1590/S1415-47572002000300002Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of boneMarcelo Razera BaruffiJ. Barbieri-NetoJoão Monteiro Pina-NetoC.E. SuerzutCacilda CasartelliCytogenetic analyses were performed on a bone giant cell reparative granuloma (GCRG) and on three bone giant cell tumors (GCT). The present GCRG case is the second to be described cytogenetically. A modal chromosome number of 46 was observed in all samples. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes 17 and 18. Among the structural anomalies observed, there was preferential involvement of chromosomes 6 and 10. Three GCT cases presented del(10)(p13) and two cases presented del(6)(q25) (1 GCRG and 1 GCT). These breakpoints mapped on 10p and 6q may harbour genes of importance in the development of bone giant cell tumors.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000300002bonegiant-cellgranulomatumorchromosome |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Marcelo Razera Baruffi J. Barbieri-Neto João Monteiro Pina-Neto C.E. Suerzut Cacilda Casartelli |
| spellingShingle |
Marcelo Razera Baruffi J. Barbieri-Neto João Monteiro Pina-Neto C.E. Suerzut Cacilda Casartelli Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone Genetics and Molecular Biology bone giant-cell granuloma tumor chromosome |
| author_facet |
Marcelo Razera Baruffi J. Barbieri-Neto João Monteiro Pina-Neto C.E. Suerzut Cacilda Casartelli |
| author_sort |
Marcelo Razera Baruffi |
| title |
Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone |
| title_short |
Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone |
| title_full |
Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone |
| title_fullStr |
Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone |
| title_full_unstemmed |
Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone |
| title_sort |
distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone |
| publisher |
Sociedade Brasileira de Genética |
| series |
Genetics and Molecular Biology |
| issn |
1415-4757 1678-4685 |
| publishDate |
2002-01-01 |
| description |
Cytogenetic analyses were performed on a bone giant cell reparative granuloma (GCRG) and on three bone giant cell tumors (GCT). The present GCRG case is the second to be described cytogenetically. A modal chromosome number of 46 was observed in all samples. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes 17 and 18. Among the structural anomalies observed, there was preferential involvement of chromosomes 6 and 10. Three GCT cases presented del(10)(p13) and two cases presented del(6)(q25) (1 GCRG and 1 GCT). These breakpoints mapped on 10p and 6q may harbour genes of importance in the development of bone giant cell tumors. |
| topic |
bone giant-cell granuloma tumor chromosome |
| url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000300002 |
| work_keys_str_mv |
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