IPP Complex Reinforces Adhesion by Relaying Tension-Dependent Signals to Inhibit Integrin Turnover

IPP Complex Reinforces Adhesion by Relaying Tension-Dependent Signals to Inhibit Integrin Turnover

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Cytoskeleton-mediated forces regulate the assembly and function of integrin adhesions; however, the underlying mechanisms remain unclear. The tripartite IPP complex, comprising ILK, Parvin, and PINCH, mediates the integrin-actin link at Drosophila embryo muscle attachment sites (MASs). Here, we demo...

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Bibliographic Details
Main Authors: Katerina M. Vakaloglou, Georgios Chrysanthis, Christos G. Zervas
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Subjects:
integrin-linked kinase
mechanotransduction
mechanosensing
endocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716301735

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http://www.sciencedirect.com/science/article/pii/S2211124716301735

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