Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α

Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α

The Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) is a transcriptional co-activator that plays a central role in adapted metabolic responses. PGC-1α is dynamically methylated and unmethylated at the residue K779 by the methyltransferase SET7/9 and the Lysine Specific...

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Main Authors: Francesca Aguilo, SiDe Li, Natarajan Balasubramaniyan, Ana Sancho, Sabina Benko, Fan Zhang, Ajay Vashisht, Madhumitha Rengasamy, Blanca Andino, Chih-hung Chen, Felix Zhou, Chengmin Qian, Ming-Ming Zhou, James A. Wohlschlegel, Weijia Zhang, Frederick J. Suchy, Martin J. Walsh
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715014849

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