Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action

Mycotoxins are highly dangerous natural compounds produced by various fungi. Enzymatic transformation seems to be the most promising method for detoxification of mycotoxins. This review summarizes current information on enzymes of different classes to convert various mycotoxins. An in-depth analysis...

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Main Authors:	Ilya Lyagin, Elena Efremenko
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	Molecules
Subjects:	enzyme mycotoxin conversion biochemical mechanism molecular modeling origins detoxification antidote
Online Access:	https://www.mdpi.com/1420-3049/24/13/2362

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spelling	doaj-4de020571813488aa5876a5dad3a01762020-11-25T00:12:12ZengMDPI AGMolecules1420-30492019-06-012413236210.3390/molecules24132362molecules24132362Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic ActionIlya Lyagin0Elena Efremenko1Faculty of Chemistry, Lomonosov Moscow State University, Moscow 119991, RussiaFaculty of Chemistry, Lomonosov Moscow State University, Moscow 119991, RussiaMycotoxins are highly dangerous natural compounds produced by various fungi. Enzymatic transformation seems to be the most promising method for detoxification of mycotoxins. This review summarizes current information on enzymes of different classes to convert various mycotoxins. An in-depth analysis of 11 key enzyme mechanisms towards dozens of major mycotoxins was realized. Additionally, molecular docking of mycotoxins to enzymes’ active centers was carried out to clarify some of these catalytic mechanisms. Analyzing protein homologues from various organisms (plants, animals, fungi, and bacteria), the prevalence and availability of natural sources of active biocatalysts with a high practical potential is discussed. The importance of multifunctional enzyme combinations for detoxification of mycotoxins is posed.https://www.mdpi.com/1420-3049/24/13/2362enzymemycotoxinconversionbiochemical mechanismmolecular modelingoriginsdetoxificationantidote
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ilya Lyagin Elena Efremenko
spellingShingle	Ilya Lyagin Elena Efremenko Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action Molecules enzyme mycotoxin conversion biochemical mechanism molecular modeling origins detoxification antidote
author_facet	Ilya Lyagin Elena Efremenko
author_sort	Ilya Lyagin
title	Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action
title_short	Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action
title_full	Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action
title_fullStr	Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action
title_full_unstemmed	Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action
title_sort	enzymes for detoxification of various mycotoxins: origins and mechanisms of catalytic action
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2019-06-01
description	Mycotoxins are highly dangerous natural compounds produced by various fungi. Enzymatic transformation seems to be the most promising method for detoxification of mycotoxins. This review summarizes current information on enzymes of different classes to convert various mycotoxins. An in-depth analysis of 11 key enzyme mechanisms towards dozens of major mycotoxins was realized. Additionally, molecular docking of mycotoxins to enzymes’ active centers was carried out to clarify some of these catalytic mechanisms. Analyzing protein homologues from various organisms (plants, animals, fungi, and bacteria), the prevalence and availability of natural sources of active biocatalysts with a high practical potential is discussed. The importance of multifunctional enzyme combinations for detoxification of mycotoxins is posed.
topic	enzyme mycotoxin conversion biochemical mechanism molecular modeling origins detoxification antidote
url	https://www.mdpi.com/1420-3049/24/13/2362
work_keys_str_mv	AT ilyalyagin enzymesfordetoxificationofvariousmycotoxinsoriginsandmechanismsofcatalyticaction AT elenaefremenko enzymesfordetoxificationofvariousmycotoxinsoriginsandmechanismsofcatalyticaction
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Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action

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