Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Abstract Background Liposarcoma (LPS) is a tumor derived from adipose tissue, and has the highest incidence among soft tissue sarcomas. Dedifferentiated liposarcoma (DDLPS) is a malignant tumor with poor prognosis. Recurrence and metastasis rates in LPS remain high even after chemotherapy and radiot...

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Bibliographic Details
Main Authors: Eun Byeol Jo, Young Sang Lee, Hyunjoo Lee, Jae Berm Park, Hyojun Park, Yoon-La Choi, Doopyo Hong, Sung Joo Kim
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Cancer
Subjects:
Human recombinant TRAIL
C-met inhibitor
Liposarcoma
DR5
C-met receptor
DR5 dependent apoptosis
Online Access:http://link.springer.com/article/10.1186/s12885-019-5713-2

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