The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö study
Abstract Aims This study aimed to investigate the association between the ‘Shrunken pore syndrome’ (SPS) and risk of death, 30 day rehospitalization, and health‐related quality of life (QoL) in heart failure (HF) patients. SPS is characterized by a difference in renal filtration between cystatin C a...
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doaj-4df6831f57d5434d8645c590f7fb75ab2021-10-08T11:50:37ZengWileyESC Heart Failure2055-58222021-10-01853577358610.1002/ehf2.13485The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö studyLiana Xhakollari0Anders Grubb1Amra Jujic2Erasmus Bachus3Peter M. Nilsson4Margret Leosdottir5Anders Christensson6Martin Magnusson7Department of Nephrology Skåne University Hospital Malmö SwedenDepartment of Clinical Chemistry Skåne University Hospital Lund SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Nephrology Skåne University Hospital Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenAbstract Aims This study aimed to investigate the association between the ‘Shrunken pore syndrome’ (SPS) and risk of death, 30 day rehospitalization, and health‐related quality of life (QoL) in heart failure (HF) patients. SPS is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatin C/eGFRcreatinine ratio. Methods and results A total of 373 patients hospitalized for HF [mean age 74.8 (±12.1) years; 118 (31.6%) women] were retrieved from the HeARt and brain failure inVESTigation trial (HARVEST‐Malmö). Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) formulas were used for estimation of glomerular filtration rate (eGFR). Presence of SPS was defined as eGFRcystatin C ≤ 60% of eGFRcreatinine. In Cox regression multivariate models, associations between SPS, risk of death (median follow‐up time 1.8 years), and risk of 30 day rehospitalization were studied. Associations between SPS and impaired QoL were studied using multivariate logistic regressions. In multivariate models, SPS was associated with all‐cause mortality [124 events; hazard ratio (HR) 1.99; 95% confidence interval (95% CI) 1.23–3.21; P = 0.005] and with 30 day rehospitalization (70 events; HR 1.82; CI 95% 1.04–3.18; P = 0.036). Analyses of QoL, based on a Kansas City Cardiomyopathy Questionnaire overall score < 50, revealed that SPS was associated with higher risk of low health‐related QoL (odds ratios 2.15; CI 95% 1.03–4.49; P = 0.042). Conclusions The results of this observational study show for the first time an association between SPS and poor prognosis in HF. Further studies are needed to confirm the results in HF cohorts and experimental settings to identify pathophysiological mechanisms.https://doi.org/10.1002/ehf2.13485Cardiorenal syndromeCreatinineCystatin CMortalityQuality of lifeShrunken pore |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liana Xhakollari Anders Grubb Amra Jujic Erasmus Bachus Peter M. Nilsson Margret Leosdottir Anders Christensson Martin Magnusson |
spellingShingle |
Liana Xhakollari Anders Grubb Amra Jujic Erasmus Bachus Peter M. Nilsson Margret Leosdottir Anders Christensson Martin Magnusson The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö study ESC Heart Failure Cardiorenal syndrome Creatinine Cystatin C Mortality Quality of life Shrunken pore |
author_facet |
Liana Xhakollari Anders Grubb Amra Jujic Erasmus Bachus Peter M. Nilsson Margret Leosdottir Anders Christensson Martin Magnusson |
author_sort |
Liana Xhakollari |
title |
The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö study |
title_short |
The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö study |
title_full |
The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö study |
title_fullStr |
The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö study |
title_full_unstemmed |
The Shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the HARVEST‐Malmö study |
title_sort |
shrunken pore syndrome is associated with poor prognosis and lower quality of life in heart failure patients: the harvest‐malmö study |
publisher |
Wiley |
series |
ESC Heart Failure |
issn |
2055-5822 |
publishDate |
2021-10-01 |
description |
Abstract Aims This study aimed to investigate the association between the ‘Shrunken pore syndrome’ (SPS) and risk of death, 30 day rehospitalization, and health‐related quality of life (QoL) in heart failure (HF) patients. SPS is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatin C/eGFRcreatinine ratio. Methods and results A total of 373 patients hospitalized for HF [mean age 74.8 (±12.1) years; 118 (31.6%) women] were retrieved from the HeARt and brain failure inVESTigation trial (HARVEST‐Malmö). Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) formulas were used for estimation of glomerular filtration rate (eGFR). Presence of SPS was defined as eGFRcystatin C ≤ 60% of eGFRcreatinine. In Cox regression multivariate models, associations between SPS, risk of death (median follow‐up time 1.8 years), and risk of 30 day rehospitalization were studied. Associations between SPS and impaired QoL were studied using multivariate logistic regressions. In multivariate models, SPS was associated with all‐cause mortality [124 events; hazard ratio (HR) 1.99; 95% confidence interval (95% CI) 1.23–3.21; P = 0.005] and with 30 day rehospitalization (70 events; HR 1.82; CI 95% 1.04–3.18; P = 0.036). Analyses of QoL, based on a Kansas City Cardiomyopathy Questionnaire overall score < 50, revealed that SPS was associated with higher risk of low health‐related QoL (odds ratios 2.15; CI 95% 1.03–4.49; P = 0.042). Conclusions The results of this observational study show for the first time an association between SPS and poor prognosis in HF. Further studies are needed to confirm the results in HF cohorts and experimental settings to identify pathophysiological mechanisms. |
topic |
Cardiorenal syndrome Creatinine Cystatin C Mortality Quality of life Shrunken pore |
url |
https://doi.org/10.1002/ehf2.13485 |
work_keys_str_mv |
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