Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%–95% yield.

Bibliographic Details
Main Authors:	Jing Lu, Youqiang Li, Changmei Si, Zhenting Du, Yin Wang
Format:	Article
Language:	English
Published:	MDPI AG 2012-04-01
Series:	International Journal of Molecular Sciences
Subjects:	silica sulfuric acid 5-substituted 1H-tetrazoles [3+2] cycloaddition
Online Access:	http://www.mdpi.com/1422-0067/13/4/4696/

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