Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats
Introduction: Recent investigations over the past decade have linked the development of hypertension to sleep loss, although the mechanisms underlying this association are still under scrutiny. To determine the relationship between sleep deprivation and cardiovascular dysfunction, we examined the ef...
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2011-09-01
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320310391504 |
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doaj-4dfe769b7f244cb3af4156747132354f2021-05-02T20:50:42ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32032011-09-011210.1177/1470320310391504Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in ratsJuliana C PerryCássia T BergamaschiRuy R CamposMonica L AndersenNicola MontanoDulce E CasariniSergio TufikIntroduction: Recent investigations over the past decade have linked the development of hypertension to sleep loss, although the mechanisms underlying this association are still under scrutiny. To determine the relationship between sleep deprivation and cardiovascular dysfunction, we examined the effects of paradoxical sleep deprivation on heart rate, blood pressure, sympathetic nerve activity (SNA) and their consequences in the blood renin—angiotensin system. Materials and methods: Wistar-Hannover male rats were randomly assigned to three experimental groups: 1) control, 2) paradoxical sleep deprivation for 24 h and 3) paradoxical sleep deprivation for 96 h. Blood pressure and heart rate were recorded in awake, freely moving rats. Results: Heart rate was higher in the 96 h paradoxical sleep deprivation group compared with the control group. Renal SNA was increased in all deprived groups. However, no significant statistical differences were observed in blood pressure or splanchnic SNA among groups. Paradoxical sleep deprivation (24 and 96 h) reduced plasma angiotensin II (Ang II) concentrations. Conclusions: The results suggest that selective sleep deprivation produces an increase in SNA, preferentially in the kidney. Thus, alterations in the sympathetic system in response to sleep loss may be an important pathway through which hypertension develops.https://doi.org/10.1177/1470320310391504 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juliana C Perry Cássia T Bergamaschi Ruy R Campos Monica L Andersen Nicola Montano Dulce E Casarini Sergio Tufik |
spellingShingle |
Juliana C Perry Cássia T Bergamaschi Ruy R Campos Monica L Andersen Nicola Montano Dulce E Casarini Sergio Tufik Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Juliana C Perry Cássia T Bergamaschi Ruy R Campos Monica L Andersen Nicola Montano Dulce E Casarini Sergio Tufik |
author_sort |
Juliana C Perry |
title |
Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats |
title_short |
Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats |
title_full |
Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats |
title_fullStr |
Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats |
title_full_unstemmed |
Sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats |
title_sort |
sympathetic and angiotensinergic responses mediated by paradoxical sleep loss in rats |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1470-3203 |
publishDate |
2011-09-01 |
description |
Introduction: Recent investigations over the past decade have linked the development of hypertension to sleep loss, although the mechanisms underlying this association are still under scrutiny. To determine the relationship between sleep deprivation and cardiovascular dysfunction, we examined the effects of paradoxical sleep deprivation on heart rate, blood pressure, sympathetic nerve activity (SNA) and their consequences in the blood renin—angiotensin system. Materials and methods: Wistar-Hannover male rats were randomly assigned to three experimental groups: 1) control, 2) paradoxical sleep deprivation for 24 h and 3) paradoxical sleep deprivation for 96 h. Blood pressure and heart rate were recorded in awake, freely moving rats. Results: Heart rate was higher in the 96 h paradoxical sleep deprivation group compared with the control group. Renal SNA was increased in all deprived groups. However, no significant statistical differences were observed in blood pressure or splanchnic SNA among groups. Paradoxical sleep deprivation (24 and 96 h) reduced plasma angiotensin II (Ang II) concentrations. Conclusions: The results suggest that selective sleep deprivation produces an increase in SNA, preferentially in the kidney. Thus, alterations in the sympathetic system in response to sleep loss may be an important pathway through which hypertension develops. |
url |
https://doi.org/10.1177/1470320310391504 |
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