The miRNA 361-3p, a Regulator of GZMB and TNF Is Associated With Therapeutic Failure and Longer Time Healing of Cutaneous Leishmaniasis Caused by L. (viannia) braziliensis

The miRNA 361-3p, a Regulator of GZMB and TNF Is Associated With Therapeutic Failure and Longer Time Healing of Cutaneous Leishmaniasis Caused by L. (viannia) braziliensis

L. (viannia) braziliensis infection causes American Tegumentary Leishmaniasis (ATL), with prolonged time to healing lesions. The potent inflammatory response developed by the host is important to control the parasite burden and infection however an unbalanced immunity may cooperate to the tissue dam...

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Bibliographic Details
Main Authors: Tainã S. Lago, Juliana Almeida Silva, Ednaldo L. Lago, Edgar M. Carvalho, Dalila L. Zanette, Léa Cristina Castellucci
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
miRNAs
American cutaneous leishmaniasis
gene expression
tissue damage
immunopathogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02621/full

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