Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation
Purpose: To evaluate the clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation (NSOI). Methods: This retrospective study evaluates 76 patients with NSOI. The patients were categorized in 9 groups according to the site o...
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Wolters Kluwer Medknow Publications
2019-09-01
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doaj-4e0c6702acc54584ba334f3420cfdc772021-04-02T11:30:00ZengWolters Kluwer Medknow PublicationsJournal of Current Ophthalmology2452-23252019-09-01313327334Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammationBahram Eshraghi0Seyed Ali Sonbolestan1Mohammad-Ali Abtahi2Arash Mirmohammadsadeghi3Ophthalmology Department, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranIsfahan University of Medical Sciences, Isfahan, Iran; Corresponding author. Daran Shahid Rajaei Hospital, Isfahan, Iran.Isfahan University of Medical Sciences, Isfahan, IranEye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranPurpose: To evaluate the clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation (NSOI). Methods: This retrospective study evaluates 76 patients with NSOI. The patients were categorized in 9 groups according to the site of involvement and histopathology results. These groups included: anterior involvement, dacryoadenitis, myositis, perineural involvement, acute fat involvement, focal mass, orbital apex involvement, diffuse sclerosing form, and multiple tissue involvement. The course of the disease was categorized as acute, subacute, or chronic. The cases with symptom duration of less than 1 week were classified as acute, 1 week to 1 month as subacute, and more than 1 month as chronic. Results: 36 (47.4%) patients were males. The mean age was 41.68 ± 17.62 (6–75) years. The most common signs and symptoms were periorbital pain, periorbital edema, decreased ocular movements or diplopia, and conjunctival injection. The most common group was dacryoadenitis in 29 (38.1%) cases. The most common form of disease was the acute involvement (50% of patients). Most of the patients were treated by oral corticosteroids. Duration of follow-up was 7.17 ± 6.26 months. Recurrence occurred in 9 (11.8%) of patients during the follow-up period. Conclusions: This study presents a new categorization in which multiple tissue involvements were separated. Some of the NSOI features differ between adults and children. In most patients, treatment especially with corticosteroids, resolves the clinical findings. Keywords: Idiopathic orbital inflammation, Clinical, Histopathology, Orbital pseudotumor, Pediatrichttp://www.sciencedirect.com/science/article/pii/S2452232518302427 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bahram Eshraghi Seyed Ali Sonbolestan Mohammad-Ali Abtahi Arash Mirmohammadsadeghi |
spellingShingle |
Bahram Eshraghi Seyed Ali Sonbolestan Mohammad-Ali Abtahi Arash Mirmohammadsadeghi Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation Journal of Current Ophthalmology |
author_facet |
Bahram Eshraghi Seyed Ali Sonbolestan Mohammad-Ali Abtahi Arash Mirmohammadsadeghi |
author_sort |
Bahram Eshraghi |
title |
Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation |
title_short |
Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation |
title_full |
Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation |
title_fullStr |
Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation |
title_full_unstemmed |
Clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation |
title_sort |
clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Current Ophthalmology |
issn |
2452-2325 |
publishDate |
2019-09-01 |
description |
Purpose: To evaluate the clinical characteristics, histopathology, and treatment outcomes in adult and pediatric patients with nonspecific orbital inflammation (NSOI). Methods: This retrospective study evaluates 76 patients with NSOI. The patients were categorized in 9 groups according to the site of involvement and histopathology results. These groups included: anterior involvement, dacryoadenitis, myositis, perineural involvement, acute fat involvement, focal mass, orbital apex involvement, diffuse sclerosing form, and multiple tissue involvement. The course of the disease was categorized as acute, subacute, or chronic. The cases with symptom duration of less than 1 week were classified as acute, 1 week to 1 month as subacute, and more than 1 month as chronic. Results: 36 (47.4%) patients were males. The mean age was 41.68 ± 17.62 (6–75) years. The most common signs and symptoms were periorbital pain, periorbital edema, decreased ocular movements or diplopia, and conjunctival injection. The most common group was dacryoadenitis in 29 (38.1%) cases. The most common form of disease was the acute involvement (50% of patients). Most of the patients were treated by oral corticosteroids. Duration of follow-up was 7.17 ± 6.26 months. Recurrence occurred in 9 (11.8%) of patients during the follow-up period. Conclusions: This study presents a new categorization in which multiple tissue involvements were separated. Some of the NSOI features differ between adults and children. In most patients, treatment especially with corticosteroids, resolves the clinical findings. Keywords: Idiopathic orbital inflammation, Clinical, Histopathology, Orbital pseudotumor, Pediatric |
url |
http://www.sciencedirect.com/science/article/pii/S2452232518302427 |
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