OX40L induces helper T cell differentiation during cell immunity of asthma through PI3K/AKT and P38 MAPK signaling pathway

OX40L induces helper T cell differentiation during cell immunity of asthma through PI3K/AKT and P38 MAPK signaling pathway

Abstract Background The aim of this study was to investigate the mechanisms of OX40L in regulating helper T (Th) cells differentiation through phosphoinositide 3-kinase (PI3K)/AKT and p38 mitogen-activated protein kinase signaling pathway in vitro and in vivo experiments. Methods Serum samples of pa...

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Bibliographic Details
Main Authors: Li Huang, Meijuan Wang, Yongdong Yan, Wenjing Gu, Xinxing Zhang, Jiahong Tan, Huiming Sun, Wei Ji, Zhengrong Chen
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Translational Medicine
Subjects:
Asthma
OX40
OX40L
PI3K/AKT
p38 MAPK
Th1
Online Access:http://link.springer.com/article/10.1186/s12967-018-1436-4

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