The Minimal Important Difference in Physical Activity in Patients with COPD.
BACKGROUND:Changes in physical activity (PA) are difficult to interpret because no framework of minimal important difference (MID) exists. We aimed to determine the minimal important difference (MID) in physical activity (PA) in patients with Chronic Obstructive Pulmonary Disease and to clinically v...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4849755?pdf=render |
id |
doaj-4e37bb7c0e434c09a42120ce7132d38f |
---|---|
record_format |
Article |
spelling |
doaj-4e37bb7c0e434c09a42120ce7132d38f2020-11-25T01:38:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015458710.1371/journal.pone.0154587The Minimal Important Difference in Physical Activity in Patients with COPD.Heleen DemeyerChris BurtinMiek HornikxCarlos Augusto CamilloHans Van RemoortelDaniel LangerWim JanssensThierry TroostersBACKGROUND:Changes in physical activity (PA) are difficult to interpret because no framework of minimal important difference (MID) exists. We aimed to determine the minimal important difference (MID) in physical activity (PA) in patients with Chronic Obstructive Pulmonary Disease and to clinically validate this MID by evaluating its impact on time to first COPD-related hospitalization. METHODS:PA was objectively measured for one week in 74 patients before and after three months of rehabilitation (rehabilitation sample). In addition the intraclass correlation coefficient was measured in 30 patients (test-retest sample), by measuring PA for two consecutive weeks. Daily number of steps was chosen as outcome measurement. Different distribution and anchor based methods were chosen to calculate the MID. Time to first hospitalization due to an exacerbation was compared between patients exceeding the MID and those who did not. RESULTS:Calculation of the MID resulted in 599 (Standard Error of Measurement), 1029 (empirical rule effect size), 1072 (Cohen's effect size) and 1131 (0.5SD) steps.day-1. An anchor based estimation could not be obtained because of the lack of a sufficiently related anchor. The time to the first hospital admission was significantly different between patients exceeding the MID and patients who did not, using the Standard Error of Measurement as cutoff. CONCLUSIONS:The MID after pulmonary rehabilitation lies between 600 and 1100 steps.day-1. The clinical importance of this change is supported by a reduced risk for hospital admission in those patients with more than 600 steps improvement.http://europepmc.org/articles/PMC4849755?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heleen Demeyer Chris Burtin Miek Hornikx Carlos Augusto Camillo Hans Van Remoortel Daniel Langer Wim Janssens Thierry Troosters |
spellingShingle |
Heleen Demeyer Chris Burtin Miek Hornikx Carlos Augusto Camillo Hans Van Remoortel Daniel Langer Wim Janssens Thierry Troosters The Minimal Important Difference in Physical Activity in Patients with COPD. PLoS ONE |
author_facet |
Heleen Demeyer Chris Burtin Miek Hornikx Carlos Augusto Camillo Hans Van Remoortel Daniel Langer Wim Janssens Thierry Troosters |
author_sort |
Heleen Demeyer |
title |
The Minimal Important Difference in Physical Activity in Patients with COPD. |
title_short |
The Minimal Important Difference in Physical Activity in Patients with COPD. |
title_full |
The Minimal Important Difference in Physical Activity in Patients with COPD. |
title_fullStr |
The Minimal Important Difference in Physical Activity in Patients with COPD. |
title_full_unstemmed |
The Minimal Important Difference in Physical Activity in Patients with COPD. |
title_sort |
minimal important difference in physical activity in patients with copd. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
BACKGROUND:Changes in physical activity (PA) are difficult to interpret because no framework of minimal important difference (MID) exists. We aimed to determine the minimal important difference (MID) in physical activity (PA) in patients with Chronic Obstructive Pulmonary Disease and to clinically validate this MID by evaluating its impact on time to first COPD-related hospitalization. METHODS:PA was objectively measured for one week in 74 patients before and after three months of rehabilitation (rehabilitation sample). In addition the intraclass correlation coefficient was measured in 30 patients (test-retest sample), by measuring PA for two consecutive weeks. Daily number of steps was chosen as outcome measurement. Different distribution and anchor based methods were chosen to calculate the MID. Time to first hospitalization due to an exacerbation was compared between patients exceeding the MID and those who did not. RESULTS:Calculation of the MID resulted in 599 (Standard Error of Measurement), 1029 (empirical rule effect size), 1072 (Cohen's effect size) and 1131 (0.5SD) steps.day-1. An anchor based estimation could not be obtained because of the lack of a sufficiently related anchor. The time to the first hospital admission was significantly different between patients exceeding the MID and patients who did not, using the Standard Error of Measurement as cutoff. CONCLUSIONS:The MID after pulmonary rehabilitation lies between 600 and 1100 steps.day-1. The clinical importance of this change is supported by a reduced risk for hospital admission in those patients with more than 600 steps improvement. |
url |
http://europepmc.org/articles/PMC4849755?pdf=render |
work_keys_str_mv |
AT heleendemeyer theminimalimportantdifferenceinphysicalactivityinpatientswithcopd AT chrisburtin theminimalimportantdifferenceinphysicalactivityinpatientswithcopd AT miekhornikx theminimalimportantdifferenceinphysicalactivityinpatientswithcopd AT carlosaugustocamillo theminimalimportantdifferenceinphysicalactivityinpatientswithcopd AT hansvanremoortel theminimalimportantdifferenceinphysicalactivityinpatientswithcopd AT daniellanger theminimalimportantdifferenceinphysicalactivityinpatientswithcopd AT wimjanssens theminimalimportantdifferenceinphysicalactivityinpatientswithcopd AT thierrytroosters theminimalimportantdifferenceinphysicalactivityinpatientswithcopd AT heleendemeyer minimalimportantdifferenceinphysicalactivityinpatientswithcopd AT chrisburtin minimalimportantdifferenceinphysicalactivityinpatientswithcopd AT miekhornikx minimalimportantdifferenceinphysicalactivityinpatientswithcopd AT carlosaugustocamillo minimalimportantdifferenceinphysicalactivityinpatientswithcopd AT hansvanremoortel minimalimportantdifferenceinphysicalactivityinpatientswithcopd AT daniellanger minimalimportantdifferenceinphysicalactivityinpatientswithcopd AT wimjanssens minimalimportantdifferenceinphysicalactivityinpatientswithcopd AT thierrytroosters minimalimportantdifferenceinphysicalactivityinpatientswithcopd |
_version_ |
1725055799764451328 |