Effects of Spinal-Z in Patients with Gastroesophageal Cancer
Objective:The purpose of this study was to investigate the efficacy and safety of spinal-Z, derived from Peganum harmala seeds and Dracocephalum Kotschyi Boiss leaves, in patients with esophageal and stomach adenocarcinoma, and squamous cell carcinoma of the esophagus.Methods:Sixty-one patients with...
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Korean Pharmacopuncture Institute
2018-03-01
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doaj-4e42a3a418b2432cab570453291f0c272020-11-25T00:29:29ZengKorean Pharmacopuncture InstituteJournal of Pharmacopuncture2093-69662234-68562018-03-0121102603410.3831/KPI.2018.21.004Effects of Spinal-Z in Patients with Gastroesophageal CancerYunes Panahi0Alireza Saadat1Maghsoud Seifi2Mahdi Rajaee3Alexandra E. Butler4Amirhossein Sahebkar5Pharmacotherapy Department, School of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, IranDepartment of Internal Medicine, Baqiyatallah University of Medical Sciences,Tehran, IranPharmacotherapy Department, School of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, IranGastrointestinal Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, IranLife Sciences Research Division, Anti-Doping Laboratory Qatar, Doha, Qatar Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranObjective:The purpose of this study was to investigate the efficacy and safety of spinal-Z, derived from Peganum harmala seeds and Dracocephalum Kotschyi Boiss leaves, in patients with esophageal and stomach adenocarcinoma, and squamous cell carcinoma of the esophagus.Methods:Sixty-one patients with malignancies of the upper gastrointestinal tract were randomly assigned to one of two groups (treatment or control) in a double-blind fashion. Six capsules of Spinal-Z were prescribed to the patients with the regimen of 600 mg/m2/ day, and placebo to the control group, for six months.Results:There were no significant differences between the two groups with regard to age, sex, duration of cancer, type of cancer and family history of cancer. There were significant differences in abdominal pain, heartburn, constipation and vomiting between the two groups, following spinal-Z therapy. Evaluation of drug side effects showed no difference in cough or other respiratory symptoms, itching, headache or dizziness between the two groups, both before and after treatment.Conclusion:This study indicates that Spinal-Z is safe and efficacious in the management of patients with upper gastrointestinal tract cancers.http://www.journal-pharm.com/sub/view/237gastroesophageal cancersadenocarcinomasquamous cell carcinomapeganum harmaladracocephalum kotschyii boissspinal-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yunes Panahi Alireza Saadat Maghsoud Seifi Mahdi Rajaee Alexandra E. Butler Amirhossein Sahebkar |
spellingShingle |
Yunes Panahi Alireza Saadat Maghsoud Seifi Mahdi Rajaee Alexandra E. Butler Amirhossein Sahebkar Effects of Spinal-Z in Patients with Gastroesophageal Cancer Journal of Pharmacopuncture gastroesophageal cancers adenocarcinoma squamous cell carcinoma peganum harmala dracocephalum kotschyii boiss spinal-z |
author_facet |
Yunes Panahi Alireza Saadat Maghsoud Seifi Mahdi Rajaee Alexandra E. Butler Amirhossein Sahebkar |
author_sort |
Yunes Panahi |
title |
Effects of Spinal-Z in Patients with Gastroesophageal Cancer |
title_short |
Effects of Spinal-Z in Patients with Gastroesophageal Cancer |
title_full |
Effects of Spinal-Z in Patients with Gastroesophageal Cancer |
title_fullStr |
Effects of Spinal-Z in Patients with Gastroesophageal Cancer |
title_full_unstemmed |
Effects of Spinal-Z in Patients with Gastroesophageal Cancer |
title_sort |
effects of spinal-z in patients with gastroesophageal cancer |
publisher |
Korean Pharmacopuncture Institute |
series |
Journal of Pharmacopuncture |
issn |
2093-6966 2234-6856 |
publishDate |
2018-03-01 |
description |
Objective:The purpose of this study was to investigate the efficacy and safety of spinal-Z, derived from Peganum harmala seeds and Dracocephalum Kotschyi Boiss leaves, in patients with esophageal and stomach adenocarcinoma, and squamous cell carcinoma of the esophagus.Methods:Sixty-one patients with malignancies of the upper gastrointestinal tract were randomly assigned to one of two groups (treatment or control) in a double-blind fashion. Six capsules of Spinal-Z were prescribed to the patients with the regimen of 600 mg/m2/ day, and placebo to the control group, for six months.Results:There were no significant differences between the two groups with regard to age, sex, duration of cancer, type of cancer and family history of cancer. There were significant differences in abdominal pain, heartburn, constipation and vomiting between the two groups, following spinal-Z therapy. Evaluation of drug side effects showed no difference in cough or other respiratory symptoms, itching, headache or dizziness between the two groups, both before and after treatment.Conclusion:This study indicates that Spinal-Z is safe and efficacious in the management of patients with upper gastrointestinal tract cancers. |
topic |
gastroesophageal cancers adenocarcinoma squamous cell carcinoma peganum harmala dracocephalum kotschyii boiss spinal-z |
url |
http://www.journal-pharm.com/sub/view/237 |
work_keys_str_mv |
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1725330927547056128 |