Bioassessment of flaxseed powder and extract against hyperglycemia and hypercholesterolemia using Sprague Dawley rats
Abstract Background Flaxseed has emerged as a potential source of bioactive components that can be utilized in routine diet to address lifestyle disorders. Methods In this context, three studies were carried out on the basis of induction therapies i.e. Study I (Normal diet), Study II (Hyperglycemic...
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doaj-4e46b34e12284416b3fca4f698f6893e2021-01-17T12:27:51ZengSpringerOpenClinical Phytoscience2199-11972020-01-016111310.1186/s40816-020-0150-yBioassessment of flaxseed powder and extract against hyperglycemia and hypercholesterolemia using Sprague Dawley ratsUmair Afzal0Masood Sadiq Butt1Faiza Ashfaq2Ahmad Bilal3Hafiz Ansar Rasul Suleria4Department of Food Processing and Preservation Technology, Government College of Technology SahiwalNational Institute of Food Science and Technology, Faculty of Food, Nutrition & Home Sciences, University of Agriculture FaisalabadDepartment of Food Science and Technology, Faculty of Science and Technology, Government College Women University FaisalabadUniversity Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of LahoreUQ Diamantina Institute, Translational Research Institute, Faculty of Medicine, The University of QueenslandAbstract Background Flaxseed has emerged as a potential source of bioactive components that can be utilized in routine diet to address lifestyle disorders. Methods In this context, three studies were carried out on the basis of induction therapies i.e. Study I (Normal diet), Study II (Hyperglycemic diet; 40% sucrose) and Study III (Hypercholesterolemic diet; 1.5% cholesterol) using Sprague Dawley rats. Each study was further split into three groups based on diets; Control (free from flaxseed powder or extract), Functional diet (incorporation of flaxseed powder; 10%) and Nutraceutical diet (inclusion of ethanolic extract of flaxseed; 5%). During experimental period, hyperglycemic and hyperlipidemic parameters were evaluated alongside, alterations in hematological aspects were also assessed. Results Feed intake and body weight demonstrated significant response (p < 0.05) of diets and study intervals however, water intake was substantially influenced by study intervals. In study II (hyperglycemic rats), maximum decline in glucose level was recorded (9.02%) in rats administered with extract based diet. In the same group, maximum increase in insulin (5.90%) was noted. Regarding lipid profile, the bioevaluation trials revealed maximum reduction in serum cholesterol (13.10%) in study III (hypercholesterolemic rats) on the provision of flaxseed extract (nutraceutical diet) followed by flaxseed powder (functional diet) i.e. 7.85%. Further, maximum decrease in low density lipoprotein-cholesterol (LDL-c) was reported i.e. 14.28% on supplementation of flaxseed extract to hypercholesterolemic rats. Conclusions Thus, flaxseed extract based intervention has shown higher bioefficacy to address hyperglycemia and hypercholesterolemia in comparison to flaxseed powder.https://doi.org/10.1186/s40816-020-0150-yLifestyle disordersFeed and water intakesBody weightFunctional dietNutraceutical diet |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Umair Afzal Masood Sadiq Butt Faiza Ashfaq Ahmad Bilal Hafiz Ansar Rasul Suleria |
spellingShingle |
Umair Afzal Masood Sadiq Butt Faiza Ashfaq Ahmad Bilal Hafiz Ansar Rasul Suleria Bioassessment of flaxseed powder and extract against hyperglycemia and hypercholesterolemia using Sprague Dawley rats Clinical Phytoscience Lifestyle disorders Feed and water intakes Body weight Functional diet Nutraceutical diet |
author_facet |
Umair Afzal Masood Sadiq Butt Faiza Ashfaq Ahmad Bilal Hafiz Ansar Rasul Suleria |
author_sort |
Umair Afzal |
title |
Bioassessment of flaxseed powder and extract against hyperglycemia and hypercholesterolemia using Sprague Dawley rats |
title_short |
Bioassessment of flaxseed powder and extract against hyperglycemia and hypercholesterolemia using Sprague Dawley rats |
title_full |
Bioassessment of flaxseed powder and extract against hyperglycemia and hypercholesterolemia using Sprague Dawley rats |
title_fullStr |
Bioassessment of flaxseed powder and extract against hyperglycemia and hypercholesterolemia using Sprague Dawley rats |
title_full_unstemmed |
Bioassessment of flaxseed powder and extract against hyperglycemia and hypercholesterolemia using Sprague Dawley rats |
title_sort |
bioassessment of flaxseed powder and extract against hyperglycemia and hypercholesterolemia using sprague dawley rats |
publisher |
SpringerOpen |
series |
Clinical Phytoscience |
issn |
2199-1197 |
publishDate |
2020-01-01 |
description |
Abstract Background Flaxseed has emerged as a potential source of bioactive components that can be utilized in routine diet to address lifestyle disorders. Methods In this context, three studies were carried out on the basis of induction therapies i.e. Study I (Normal diet), Study II (Hyperglycemic diet; 40% sucrose) and Study III (Hypercholesterolemic diet; 1.5% cholesterol) using Sprague Dawley rats. Each study was further split into three groups based on diets; Control (free from flaxseed powder or extract), Functional diet (incorporation of flaxseed powder; 10%) and Nutraceutical diet (inclusion of ethanolic extract of flaxseed; 5%). During experimental period, hyperglycemic and hyperlipidemic parameters were evaluated alongside, alterations in hematological aspects were also assessed. Results Feed intake and body weight demonstrated significant response (p < 0.05) of diets and study intervals however, water intake was substantially influenced by study intervals. In study II (hyperglycemic rats), maximum decline in glucose level was recorded (9.02%) in rats administered with extract based diet. In the same group, maximum increase in insulin (5.90%) was noted. Regarding lipid profile, the bioevaluation trials revealed maximum reduction in serum cholesterol (13.10%) in study III (hypercholesterolemic rats) on the provision of flaxseed extract (nutraceutical diet) followed by flaxseed powder (functional diet) i.e. 7.85%. Further, maximum decrease in low density lipoprotein-cholesterol (LDL-c) was reported i.e. 14.28% on supplementation of flaxseed extract to hypercholesterolemic rats. Conclusions Thus, flaxseed extract based intervention has shown higher bioefficacy to address hyperglycemia and hypercholesterolemia in comparison to flaxseed powder. |
topic |
Lifestyle disorders Feed and water intakes Body weight Functional diet Nutraceutical diet |
url |
https://doi.org/10.1186/s40816-020-0150-y |
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