Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer
Background and objective uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC). Methods Expressions of uPA and ET-1 prote...
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2011-01-01
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Online Access: | http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2011.01.10&path[]=3091 |
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doaj-4e4e949bbcc74a9d861a5fce87bf08ce2020-11-24T23:08:28ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872011-01-011414953Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung CancerYanyi JIANGYizhen LIUZhizhou SHIBoshi WANGLi SHANGXin XUShengzhou ZHANGMingrong WANGBackground and objective uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC). Methods Expressions of uPA and ET-1 protein were detected in 155 cases of NSCLC with tissue microarrays and immunohistochemistry (TMA-IHC) technique. The correlations between the alteration of the two proteins and clinicopathological parameters were analyzed. Results Negative/weak, moderate and high expression of uPA were observed in 12.3%, 64.4% and 23.3% of squamous cell carcinomas, in 12.2%, 53.7% and 34.1% of adenocarcinomas, and in 12.3%, 58.7% and 29.0% of all cases. ET-1 presented negative/weak, moderate and high expression in 2.7%, 42.5% and 54.8% of squamous cell carcinomas, in 11.0%, 30.5% and 58.5% of adenocarcinomas, and in 7.1%, 36.1% and 56.8% of all cases. Simultaneously high expression of uPA and ET-1 were found in adenocarcinomas without lymph node metastasis (P=0.017). Adenocarcinoma patients with high expression of uPA or with high expression of both ET-1 and uPA had the longer survival time (P=0.007 and 0.016). Conclusion Detection of uPA and ET-1 protein levels might contribute to the prognosis evaluation of NSCLC.http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2011.01.10&path[]=3091Lung neoplasmsuPAET-1ImmunohistochemistryPrognosis |
collection |
DOAJ |
language |
zho |
format |
Article |
sources |
DOAJ |
author |
Yanyi JIANG Yizhen LIU Zhizhou SHI Boshi WANG Li SHANG Xin XU Shengzhou ZHANG Mingrong WANG |
spellingShingle |
Yanyi JIANG Yizhen LIU Zhizhou SHI Boshi WANG Li SHANG Xin XU Shengzhou ZHANG Mingrong WANG Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms uPA ET-1 Immunohistochemistry Prognosis |
author_facet |
Yanyi JIANG Yizhen LIU Zhizhou SHI Boshi WANG Li SHANG Xin XU Shengzhou ZHANG Mingrong WANG |
author_sort |
Yanyi JIANG |
title |
Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer |
title_short |
Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer |
title_full |
Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer |
title_fullStr |
Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer |
title_full_unstemmed |
Expression and Clinical Relevance of uPA and ET-1 in Non-small Cell Lung Cancer |
title_sort |
expression and clinical relevance of upa and et-1 in non-small cell lung cancer |
publisher |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
series |
Chinese Journal of Lung Cancer |
issn |
1009-3419 1999-6187 |
publishDate |
2011-01-01 |
description |
Background and objective uPA and ET-1 proteins have been reported to be up-regulated in some of human cancers. The aim of this study is to investigate the alteration and clinical relevance of uPA and ET-1 protein levels in non-small cell lung cancer (NSCLC). Methods Expressions of uPA and ET-1 protein were detected in 155 cases of NSCLC with tissue microarrays and immunohistochemistry (TMA-IHC) technique. The correlations between the alteration of the two proteins and clinicopathological parameters were analyzed. Results Negative/weak, moderate and high expression of uPA were observed in 12.3%, 64.4% and 23.3% of squamous cell carcinomas, in 12.2%, 53.7% and 34.1% of adenocarcinomas, and in 12.3%, 58.7% and 29.0% of all cases. ET-1 presented negative/weak, moderate and high expression in 2.7%, 42.5% and 54.8% of squamous cell carcinomas, in 11.0%, 30.5% and 58.5% of adenocarcinomas, and in 7.1%, 36.1% and 56.8% of all cases. Simultaneously high expression of uPA and ET-1 were found in adenocarcinomas without lymph node metastasis (P=0.017). Adenocarcinoma patients with high expression of uPA or with high expression of both ET-1 and uPA had the longer survival time (P=0.007 and 0.016). Conclusion Detection of uPA and ET-1 protein levels might contribute to the prognosis evaluation of NSCLC. |
topic |
Lung neoplasms uPA ET-1 Immunohistochemistry Prognosis |
url |
http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2011.01.10&path[]=3091 |
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