Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease
MicroRNAs (miRNAs) are short sequences of non-coding RNA that play an important role in the regulation of gene expression and thereby in many physiological and pathological processes. Furthermore, miRNAs are released in the extracellular space, for example in vesicles, and are detectable in various...
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doaj-4e51a0338aa641f580a9a917197320b92020-11-25T03:07:14ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-07-011110.3389/fphys.2020.00793556482Small Things Matter: Relevance of MicroRNAs in Cardiovascular DiseaseLinsey J. F. Peters0Linsey J. F. Peters1Linsey J. F. Peters2Linsey J. F. Peters3Erik A. L. Biessen4Erik A. L. Biessen5Mathias Hohl6Christian Weber7Christian Weber8Christian Weber9Christian Weber10Emiel P. C. van der Vorst11Emiel P. C. van der Vorst12Emiel P. C. van der Vorst13Emiel P. C. van der Vorst14Emiel P. C. van der Vorst15Donato Santovito16Donato Santovito17Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, GermanyDepartment of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsInterdisciplinary Center for Clinical Research, RWTH Aachen University, Aachen, GermanyGerman Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, GermanyInstitute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, GermanyDepartment of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsKlinik für Innere Medizin III, Universität des Saarlandes, Homburg, GermanyGerman Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, GermanyInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, GermanyDepartment of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsMunich Cluster for Systems Neurology, Munich, GermanyInstitute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, GermanyDepartment of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsInterdisciplinary Center for Clinical Research, RWTH Aachen University, Aachen, GermanyGerman Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, GermanyInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, GermanyGerman Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, GermanyInstitute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, GermanyMicroRNAs (miRNAs) are short sequences of non-coding RNA that play an important role in the regulation of gene expression and thereby in many physiological and pathological processes. Furthermore, miRNAs are released in the extracellular space, for example in vesicles, and are detectable in various biological fluids, such as serum, plasma, and urine. Over the last years, it has been shown that miRNAs are crucial in the development of several cardiovascular diseases (CVDs). This review discusses the (patho)physiological implications of miRNAs in CVD, ranging from cardiovascular risk factors (i.e., hypertension, diabetes, dyslipidemia), to atherosclerosis, myocardial infarction, and cardiac remodeling. Moreover, the intriguing possibility of their use as disease-specific diagnostic and prognostic biomarkers for human CVDs will be discussed in detail. Finally, as several approaches have been developed to alter miRNA expression and function (i.e., mimics, antagomirs, and target-site blockers), we will highlight the miRNAs with the most promising therapeutic potential that may represent suitable candidates for therapeutic intervention in future translational studies and ultimately in clinical trials. All in all, this review gives a comprehensive overview of the most relevant miRNAs in CVD and discusses their potential use as biomarkers and even therapeutic targets.https://www.frontiersin.org/article/10.3389/fphys.2020.00793/fullmicroRNAscardiovascular diseasescardiovascular risk factorsatherosclerosismyocardial infarctioncardiac remodeling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Linsey J. F. Peters Linsey J. F. Peters Linsey J. F. Peters Linsey J. F. Peters Erik A. L. Biessen Erik A. L. Biessen Mathias Hohl Christian Weber Christian Weber Christian Weber Christian Weber Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Donato Santovito Donato Santovito |
spellingShingle |
Linsey J. F. Peters Linsey J. F. Peters Linsey J. F. Peters Linsey J. F. Peters Erik A. L. Biessen Erik A. L. Biessen Mathias Hohl Christian Weber Christian Weber Christian Weber Christian Weber Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Donato Santovito Donato Santovito Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease Frontiers in Physiology microRNAs cardiovascular diseases cardiovascular risk factors atherosclerosis myocardial infarction cardiac remodeling |
author_facet |
Linsey J. F. Peters Linsey J. F. Peters Linsey J. F. Peters Linsey J. F. Peters Erik A. L. Biessen Erik A. L. Biessen Mathias Hohl Christian Weber Christian Weber Christian Weber Christian Weber Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Emiel P. C. van der Vorst Donato Santovito Donato Santovito |
author_sort |
Linsey J. F. Peters |
title |
Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease |
title_short |
Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease |
title_full |
Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease |
title_fullStr |
Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease |
title_full_unstemmed |
Small Things Matter: Relevance of MicroRNAs in Cardiovascular Disease |
title_sort |
small things matter: relevance of micrornas in cardiovascular disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2020-07-01 |
description |
MicroRNAs (miRNAs) are short sequences of non-coding RNA that play an important role in the regulation of gene expression and thereby in many physiological and pathological processes. Furthermore, miRNAs are released in the extracellular space, for example in vesicles, and are detectable in various biological fluids, such as serum, plasma, and urine. Over the last years, it has been shown that miRNAs are crucial in the development of several cardiovascular diseases (CVDs). This review discusses the (patho)physiological implications of miRNAs in CVD, ranging from cardiovascular risk factors (i.e., hypertension, diabetes, dyslipidemia), to atherosclerosis, myocardial infarction, and cardiac remodeling. Moreover, the intriguing possibility of their use as disease-specific diagnostic and prognostic biomarkers for human CVDs will be discussed in detail. Finally, as several approaches have been developed to alter miRNA expression and function (i.e., mimics, antagomirs, and target-site blockers), we will highlight the miRNAs with the most promising therapeutic potential that may represent suitable candidates for therapeutic intervention in future translational studies and ultimately in clinical trials. All in all, this review gives a comprehensive overview of the most relevant miRNAs in CVD and discusses their potential use as biomarkers and even therapeutic targets. |
topic |
microRNAs cardiovascular diseases cardiovascular risk factors atherosclerosis myocardial infarction cardiac remodeling |
url |
https://www.frontiersin.org/article/10.3389/fphys.2020.00793/full |
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