Small Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes

Small Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes

The small molecule cyclotriazadisulfonamide (CADA) down-modulates the human CD4 receptor, an important factor in T cell activation. Here, we addressed the immunosuppressive potential of CADA using different activation models. CADA inhibited lymphocyte proliferation with low cellular toxicity in a mi...

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Bibliographic Details
Main Authors: Elisa Claeys, Eva Pauwels, Stephanie Humblet-Baron, Becky Provinciael, Dominique Schols, Mark Waer, Ben Sprangers, Kurt Vermeire
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
cyclotriazadisulfonamide (CADA)
CD4 receptor
T cell activation
immunosuppression
4-1BB (CD137)
signal peptide
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.650731/full

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