Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics
Abstract Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA survival rates in people not having improved in decades. For dogs, 1 year survival rates are only around ~ 45%...
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doaj-4e559c65a66f487d84bd3acc9f47b1312020-11-24T21:47:45ZengBMCActa Veterinaria Scandinavica1751-01472017-10-0159111110.1186/s13028-017-0341-9Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and geneticsSiobhan Simpson0Mark David Dunning1Simone de Brot2Llorenç Grau-Roma3Nigel Patrick Mongan4Catrin Sian Rutland5Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington CampusFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington CampusFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington CampusFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington CampusFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington CampusFaculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington CampusAbstract Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA survival rates in people not having improved in decades. For dogs, 1 year survival rates are only around ~ 45%. Improved and novel treatment regimens are urgently required to improve survival in both humans and dogs with OSA. Utilising information from genetic studies could assist in this in both species, with the higher incidence rates in dogs contributing to the dog population being a good model of human disease. This review compares the clinical characteristics, gross morphology and histopathology, aetiology, epidemiology, and genetics of canine and human OSA. Finally, the current position of canine OSA genetic research is discussed and areas for additional work within the canine population are identified.http://link.springer.com/article/10.1186/s13028-017-0341-9Bone cancerCanineGeneticsHumanMolecular diagnosticsOsteosarcoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siobhan Simpson Mark David Dunning Simone de Brot Llorenç Grau-Roma Nigel Patrick Mongan Catrin Sian Rutland |
spellingShingle |
Siobhan Simpson Mark David Dunning Simone de Brot Llorenç Grau-Roma Nigel Patrick Mongan Catrin Sian Rutland Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics Acta Veterinaria Scandinavica Bone cancer Canine Genetics Human Molecular diagnostics Osteosarcoma |
author_facet |
Siobhan Simpson Mark David Dunning Simone de Brot Llorenç Grau-Roma Nigel Patrick Mongan Catrin Sian Rutland |
author_sort |
Siobhan Simpson |
title |
Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
title_short |
Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
title_full |
Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
title_fullStr |
Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
title_full_unstemmed |
Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
title_sort |
comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics |
publisher |
BMC |
series |
Acta Veterinaria Scandinavica |
issn |
1751-0147 |
publishDate |
2017-10-01 |
description |
Abstract Osteosarcoma (OSA) is a rare cancer in people. However OSA incidence rates in dogs are 27 times higher than in people. Prognosis in both species is relatively poor, with 5 year OSA survival rates in people not having improved in decades. For dogs, 1 year survival rates are only around ~ 45%. Improved and novel treatment regimens are urgently required to improve survival in both humans and dogs with OSA. Utilising information from genetic studies could assist in this in both species, with the higher incidence rates in dogs contributing to the dog population being a good model of human disease. This review compares the clinical characteristics, gross morphology and histopathology, aetiology, epidemiology, and genetics of canine and human OSA. Finally, the current position of canine OSA genetic research is discussed and areas for additional work within the canine population are identified. |
topic |
Bone cancer Canine Genetics Human Molecular diagnostics Osteosarcoma |
url |
http://link.springer.com/article/10.1186/s13028-017-0341-9 |
work_keys_str_mv |
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