Triple visual hemifield maps in a case of optic chiasm hypoplasia
In humans, each hemisphere comprises an overlay of two visuotopic maps of the contralateral visual field, one from each eye. Is the capacity of the visual cortex limited to these two maps or are plastic mechanisms available to host more maps? We determined the cortical organization of the visual fie...
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doaj-4e5896dfbb384ca390a188beef46ce5a2020-11-25T02:58:37ZengElsevierNeuroImage1095-95722020-07-01215116822Triple visual hemifield maps in a case of optic chiasm hypoplasiaKhazar Ahmadi0Alessio Fracasso1Robert J. Puzniak2Andre D. Gouws3Renat Yakupov4Oliver Speck5Joern Kaufmann6Franco Pestilli7Serge O. Dumoulin8Antony B. Morland9Michael B. Hoffmann10Department of Ophthalmology, Otto-von-Guericke University, Magdeburg, 39120, Germany; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, 22362, SwedenDepartment of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, 3584 CS, the Netherlands; Department of Radiology, University Medical Center Utrecht, Utrecht, 3584 CX, the Netherlands; Spinoza Centre for Neuroimaging, Amsterdam, 1105 BK, the Netherlands; Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, G12 8QB, UKDepartment of Ophthalmology, Otto-von-Guericke University, Magdeburg, 39120, GermanyDepartment of Psychology, York Neuroimaging Centre, University of York, York, YO10 5NY, UKDepartment of Biomedical Magnetic Resonance, Institute for Physics, Otto-von-Guericke University, Magdeburg, 39120, Germany; German Center for Neurodegenerative Diseases, Magdeburg, 39120, GermanyDepartment of Biomedical Magnetic Resonance, Institute for Physics, Otto-von-Guericke University, Magdeburg, 39120, Germany; German Center for Neurodegenerative Diseases, Magdeburg, 39120, Germany; Leibniz Institute for Neurobiology, Magdeburg, 39118, Germany; Center for Behavioral Brain Sciences, Magdeburg, 39106, GermanyDepartment of Neurology, Otto-von-Guericke-University, Magdeburg, 39120, GermanyDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 1101 E, USADepartment of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, 3584 CS, the Netherlands; Spinoza Centre for Neuroimaging, Amsterdam, 1105 BK, the Netherlands; Department of Experimental and Applied Psychology, VU University Amsterdam, Amsterdam, 1081 BT, the NetherlandsDepartment of Psychology, York Neuroimaging Centre, University of York, York, YO10 5NY, UK; Centre for Neuroscience, Hull-York Medical School, University of York, York, YO10 5DD, UKDepartment of Ophthalmology, Otto-von-Guericke University, Magdeburg, 39120, Germany; Center for Behavioral Brain Sciences, Magdeburg, 39106, Germany; Corresponding author. Department of Ophthalmology, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany.In humans, each hemisphere comprises an overlay of two visuotopic maps of the contralateral visual field, one from each eye. Is the capacity of the visual cortex limited to these two maps or are plastic mechanisms available to host more maps? We determined the cortical organization of the visual field maps in a rare individual with chiasma hypoplasia, where visual cortex plasticity is challenged to accommodate three hemifield maps. Using high-resolution fMRI at 7T and diffusion-weighted MRI at 3T, we found three hemiretinal inputs, instead of the normal two, to converge onto the left hemisphere. fMRI-based population receptive field mapping of the left V1–V3 at 3T revealed three superimposed hemifield representations in the left visual cortex, i.e. two representations of opposing visual hemifields from the left eye and one right hemifield representation from the right eye. We conclude that developmental plasticity including the re-wiring of local intra- and cortico-cortical connections is pivotal to support the coexistence and functioning of three hemifield maps within one hemisphere.http://www.sciencedirect.com/science/article/pii/S1053811920303098DWIfMRIOptic chiasmPlasticityRetinotopyVisual cortex |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Khazar Ahmadi Alessio Fracasso Robert J. Puzniak Andre D. Gouws Renat Yakupov Oliver Speck Joern Kaufmann Franco Pestilli Serge O. Dumoulin Antony B. Morland Michael B. Hoffmann |
spellingShingle |
Khazar Ahmadi Alessio Fracasso Robert J. Puzniak Andre D. Gouws Renat Yakupov Oliver Speck Joern Kaufmann Franco Pestilli Serge O. Dumoulin Antony B. Morland Michael B. Hoffmann Triple visual hemifield maps in a case of optic chiasm hypoplasia NeuroImage DWI fMRI Optic chiasm Plasticity Retinotopy Visual cortex |
author_facet |
Khazar Ahmadi Alessio Fracasso Robert J. Puzniak Andre D. Gouws Renat Yakupov Oliver Speck Joern Kaufmann Franco Pestilli Serge O. Dumoulin Antony B. Morland Michael B. Hoffmann |
author_sort |
Khazar Ahmadi |
title |
Triple visual hemifield maps in a case of optic chiasm hypoplasia |
title_short |
Triple visual hemifield maps in a case of optic chiasm hypoplasia |
title_full |
Triple visual hemifield maps in a case of optic chiasm hypoplasia |
title_fullStr |
Triple visual hemifield maps in a case of optic chiasm hypoplasia |
title_full_unstemmed |
Triple visual hemifield maps in a case of optic chiasm hypoplasia |
title_sort |
triple visual hemifield maps in a case of optic chiasm hypoplasia |
publisher |
Elsevier |
series |
NeuroImage |
issn |
1095-9572 |
publishDate |
2020-07-01 |
description |
In humans, each hemisphere comprises an overlay of two visuotopic maps of the contralateral visual field, one from each eye. Is the capacity of the visual cortex limited to these two maps or are plastic mechanisms available to host more maps? We determined the cortical organization of the visual field maps in a rare individual with chiasma hypoplasia, where visual cortex plasticity is challenged to accommodate three hemifield maps. Using high-resolution fMRI at 7T and diffusion-weighted MRI at 3T, we found three hemiretinal inputs, instead of the normal two, to converge onto the left hemisphere. fMRI-based population receptive field mapping of the left V1–V3 at 3T revealed three superimposed hemifield representations in the left visual cortex, i.e. two representations of opposing visual hemifields from the left eye and one right hemifield representation from the right eye. We conclude that developmental plasticity including the re-wiring of local intra- and cortico-cortical connections is pivotal to support the coexistence and functioning of three hemifield maps within one hemisphere. |
topic |
DWI fMRI Optic chiasm Plasticity Retinotopy Visual cortex |
url |
http://www.sciencedirect.com/science/article/pii/S1053811920303098 |
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