How Do Cytokines Trigger Genomic Instability?

How Do Cytokines Trigger Genomic Instability?

Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in th...

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Main Authors: Ioannis L. Aivaliotis, Ioannis S. Pateras, Marilena Papaioannou, Christina Glytsou, Konstantinos Kontzoglou, Elizabeth O. Johnson, Vassilis Zoumpourlis
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2012/536761
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spelling doaj-4e607d1f92c44f6d83c48ce0f26453b72020-11-25T01:40:08ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512012-01-01201210.1155/2012/536761536761How Do Cytokines Trigger Genomic Instability?Ioannis L. Aivaliotis0Ioannis S. Pateras1Marilena Papaioannou2Christina Glytsou3Konstantinos Kontzoglou4Elizabeth O. Johnson5Vassilis Zoumpourlis6Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece2nd Department of Propedeutic Surgery, Laikon General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Anatomy, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceInstitute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, 11635 Athens, GreeceInflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in the interaction between the cells of tumor microenvironment. A comprehensive study of the role of cytokines in the context of the inflammation-tumorigenesis interplay helps us to shed light in the pathogenesis of cancer. In this paper we focus on the role of cytokines in the development of genomic instability, an evolving hallmark of cancer.http://dx.doi.org/10.1155/2012/536761
collection DOAJ
language English
format Article
sources DOAJ
author Ioannis L. Aivaliotis
Ioannis S. Pateras
Marilena Papaioannou
Christina Glytsou
Konstantinos Kontzoglou
Elizabeth O. Johnson
Vassilis Zoumpourlis
spellingShingle Ioannis L. Aivaliotis
Ioannis S. Pateras
Marilena Papaioannou
Christina Glytsou
Konstantinos Kontzoglou
Elizabeth O. Johnson
Vassilis Zoumpourlis
How Do Cytokines Trigger Genomic Instability?
Journal of Biomedicine and Biotechnology
author_facet Ioannis L. Aivaliotis
Ioannis S. Pateras
Marilena Papaioannou
Christina Glytsou
Konstantinos Kontzoglou
Elizabeth O. Johnson
Vassilis Zoumpourlis
author_sort Ioannis L. Aivaliotis
title How Do Cytokines Trigger Genomic Instability?
title_short How Do Cytokines Trigger Genomic Instability?
title_full How Do Cytokines Trigger Genomic Instability?
title_fullStr How Do Cytokines Trigger Genomic Instability?
title_full_unstemmed How Do Cytokines Trigger Genomic Instability?
title_sort how do cytokines trigger genomic instability?
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2012-01-01
description Inflammation is a double-edged sword presenting a dual effect on cancer development, from one hand promoting tumor initiation and progression and from the other hand protecting against cancer through immunosurveillance mechanisms. Cytokines are crucial components of inflammation, participating in the interaction between the cells of tumor microenvironment. A comprehensive study of the role of cytokines in the context of the inflammation-tumorigenesis interplay helps us to shed light in the pathogenesis of cancer. In this paper we focus on the role of cytokines in the development of genomic instability, an evolving hallmark of cancer.
url http://dx.doi.org/10.1155/2012/536761
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