Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.
Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and delivers into their cytosol an adenylyl cyclase (AC) enzyme that subverts cellular signaling by increasing cAMP levels. In the present study, w...
Main Authors: | Irena Adkins, Jana Kamanova, Aneta Kocourkova, Martina Svedova, Jakub Tomala, Hana Janova, Jiri Masin, Barbora Chladkova, Ladislav Bumba, Marek Kovar, Padraig J Ross, Ludmila Tuckova, Radek Spisek, Kingston H G Mills, Peter Sebo |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4118975?pdf=render |
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