Human Umbilical Cord Blood Cell Grafts for Brain Ischemia
Irreversible and permanent damage develop immediately adjacent to the region of reduced cerebral blood perfusion in stroke patients. Currently, the proven thrombolytic treatment for stroke, tissue plasminogen activator, is only effective when administered within 3 h after stroke. These disease chara...
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2009-09-01
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Series: | Cell Transplantation |
Online Access: | https://doi.org/10.3727/096368909X471279 |
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doaj-4e6510e894224a00927a6cd05bd6608e2020-11-25T03:39:32ZengSAGE PublishingCell Transplantation0963-68971555-38922009-09-011810.3727/096368909X471279Human Umbilical Cord Blood Cell Grafts for Brain IschemiaDong-Hyuk Park0Cesar V. Borlongan1Alison E. Willing2David J. Eve3L. Eduardo Cruz4Cyndy D. Sanberg5Yong-Gu Chung6Paul R. Sanberg7Department of Neurosurgery, Korea University Medical Center, Korea University College of Medicine, Seoul, KoreaCenter of Excellence for Aging & Brain Repair, Department of Neurosurgery & Brain Repair, University of South Florida College of Medicine, Tampa, FL, USACenter of Excellence for Aging & Brain Repair, Department of Neurosurgery & Brain Repair, University of South Florida College of Medicine, Tampa, FL, USACenter of Excellence for Aging & Brain Repair, Department of Neurosurgery & Brain Repair, University of South Florida College of Medicine, Tampa, FL, USACryopraxis and Silvestre Laboratory, Cryopraxis, BioRio, Pólo de Biotechnologia do Rio de Janeiro, Rio di Janiero, BrazilSaneron CCEL Therapeutics, Inc., Tampa, FL, USACryopraxis and Silvestre Laboratory, Cryopraxis, BioRio, Pólo de Biotechnologia do Rio de Janeiro, Rio di Janiero, BrazilOffice of Research and Innovation, University of South Florida, Tampa, FL, USAIrreversible and permanent damage develop immediately adjacent to the region of reduced cerebral blood perfusion in stroke patients. Currently, the proven thrombolytic treatment for stroke, tissue plasminogen activator, is only effective when administered within 3 h after stroke. These disease characteristics should be taken under consideration in developing any therapeutic intervention designed to widen the narrow therapeutic range, especially cell-based therapy. Over the past several years, our group and others have characterized the therapeutic potential of human umbilical cord blood cells for stroke and other neurological disorders using in vitro and vivo models focusing on the cells' ability to differentiate into nonhematopoietic cells including neural lineage, as well as their ability to produce several neurotrophic factors and modulate immune and inflammatory reaction. Rather than the conventional cell replacement mechanism, we advance alternative pathways of graft-mediated brain repair involving neurotrophic effects resulting from release of various growth factors that afford cell survival, angiogenesis, and anti-inflammation. Eventually, these multiple protective and restorative effects from umbilical cord blood cell grafts may be interdependent and act in harmony in promoting therapeutic benefits for stroke.https://doi.org/10.3727/096368909X471279 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dong-Hyuk Park Cesar V. Borlongan Alison E. Willing David J. Eve L. Eduardo Cruz Cyndy D. Sanberg Yong-Gu Chung Paul R. Sanberg |
spellingShingle |
Dong-Hyuk Park Cesar V. Borlongan Alison E. Willing David J. Eve L. Eduardo Cruz Cyndy D. Sanberg Yong-Gu Chung Paul R. Sanberg Human Umbilical Cord Blood Cell Grafts for Brain Ischemia Cell Transplantation |
author_facet |
Dong-Hyuk Park Cesar V. Borlongan Alison E. Willing David J. Eve L. Eduardo Cruz Cyndy D. Sanberg Yong-Gu Chung Paul R. Sanberg |
author_sort |
Dong-Hyuk Park |
title |
Human Umbilical Cord Blood Cell Grafts for Brain Ischemia |
title_short |
Human Umbilical Cord Blood Cell Grafts for Brain Ischemia |
title_full |
Human Umbilical Cord Blood Cell Grafts for Brain Ischemia |
title_fullStr |
Human Umbilical Cord Blood Cell Grafts for Brain Ischemia |
title_full_unstemmed |
Human Umbilical Cord Blood Cell Grafts for Brain Ischemia |
title_sort |
human umbilical cord blood cell grafts for brain ischemia |
publisher |
SAGE Publishing |
series |
Cell Transplantation |
issn |
0963-6897 1555-3892 |
publishDate |
2009-09-01 |
description |
Irreversible and permanent damage develop immediately adjacent to the region of reduced cerebral blood perfusion in stroke patients. Currently, the proven thrombolytic treatment for stroke, tissue plasminogen activator, is only effective when administered within 3 h after stroke. These disease characteristics should be taken under consideration in developing any therapeutic intervention designed to widen the narrow therapeutic range, especially cell-based therapy. Over the past several years, our group and others have characterized the therapeutic potential of human umbilical cord blood cells for stroke and other neurological disorders using in vitro and vivo models focusing on the cells' ability to differentiate into nonhematopoietic cells including neural lineage, as well as their ability to produce several neurotrophic factors and modulate immune and inflammatory reaction. Rather than the conventional cell replacement mechanism, we advance alternative pathways of graft-mediated brain repair involving neurotrophic effects resulting from release of various growth factors that afford cell survival, angiogenesis, and anti-inflammation. Eventually, these multiple protective and restorative effects from umbilical cord blood cell grafts may be interdependent and act in harmony in promoting therapeutic benefits for stroke. |
url |
https://doi.org/10.3727/096368909X471279 |
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