Eomes Impedes Durable Response to Tumor Immunotherapy by Inhibiting Stemness, Tissue Residency, and Promoting the Dysfunctional State of Intratumoral CD8+ T Cells

Eomes Impedes Durable Response to Tumor Immunotherapy by Inhibiting Stemness, Tissue Residency, and Promoting the Dysfunctional State of Intratumoral CD8+ T Cells

Sustaining efficacious T cell-mediated antitumor immune responses in the tumor tissues is the key to the success of cancer immunotherapy. Current strategies leverage altering the signals T cells sense in the tumor microenvironment (TME). Checkpoint inhibitor-based approaches block inhibitory signals...

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Bibliographic Details
Main Authors: Runzi Sun, Yixian Wu, Huijun Zhou, Yanshi Wu, Zhongzhou Yang, Yanzheng Gu, Jingting Jiang, Binfeng Lu, Yibei Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tumor immunotherapy
tissue residency
T cell dysfunction
stem-like T cell
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.640224/full

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