Retinal thickness as a potential biomarker in patients with amyloid‐proven early‐ and late‐onset Alzheimer's disease
Abstract Introduction Retinal thickness measured with optical coherence tomography has been proposed as a noninvasive biomarker for Alzheimer's disease (AD). We therefore measured retinal thickness in well‐characterized AD and control participants, considering ophthalmological confounders. Meth...
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doaj-4e69b77c21d94f5fa600d6f36d76c4572020-11-25T03:02:58ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292019-12-0111146347110.1016/j.dadm.2019.05.002Retinal thickness as a potential biomarker in patients with amyloid‐proven early‐ and late‐onset Alzheimer's diseaseJurre denHaan0Jacoba A. van deKreeke1Elles Konijnenberg2Mara tenKate3Anouk denBraber4Frederik Barkhof5Bart N. vanBerckel6Charlotte E. Teunissen7Philip Scheltens8Pieter Jelle Visser9Frank D. Verbraak10Femke H. Bouwman11Department of NeurologyAlzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of Ophthalmology, Amsterdam NeuroscienceAmsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of NeurologyAlzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of NeurologyAlzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of NeurologyAlzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of Radiology and Nuclear Medicine, Amsterdam NeuroscienceAmsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of Radiology and Nuclear Medicine, Amsterdam NeuroscienceAmsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of Clinical ChemistryNeurochemistry Lab and Biobank, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of NeurologyAlzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of NeurologyAlzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of Ophthalmology, Amsterdam NeuroscienceAmsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsDepartment of NeurologyAlzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit AmsterdamAmsterdamthe NetherlandsAbstract Introduction Retinal thickness measured with optical coherence tomography has been proposed as a noninvasive biomarker for Alzheimer's disease (AD). We therefore measured retinal thickness in well‐characterized AD and control participants, considering ophthalmological confounders. Methods We included 57 amyloid‐proven AD cases and 85 cognitively normal, amyloid‐negative controls. All subjects underwent retinal thickness measurements with spectral domain optical coherence tomography and an ophthalmological assessment to exclude ocular disease. Results Retinal thickness did not discriminate cases from controls, including stratified analyses for early‐ versus late‐onset AD. We found significant associations between macular thickness and global cortical atrophy [β −0.358; P = .01] and parietal cortical atrophy on magnetic resonance imaging [β −0.371; P < .01] in AD cases. Discussion In this study, representing the largest optical coherence tomography cohort with amyloid‐proven AD cases, we show that retinal thickness does not discriminate AD from controls, despite evident changes on clinical, neuroimaging, and CSF measures, querying the use of retinal thickness measurements as an AD biomarker.https://doi.org/10.1016/j.dadm.2019.05.002Retinal thicknessCortical atrophyAlzheimer's diseaseNeurodegenerationBiomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jurre denHaan Jacoba A. van deKreeke Elles Konijnenberg Mara tenKate Anouk denBraber Frederik Barkhof Bart N. vanBerckel Charlotte E. Teunissen Philip Scheltens Pieter Jelle Visser Frank D. Verbraak Femke H. Bouwman |
spellingShingle |
Jurre denHaan Jacoba A. van deKreeke Elles Konijnenberg Mara tenKate Anouk denBraber Frederik Barkhof Bart N. vanBerckel Charlotte E. Teunissen Philip Scheltens Pieter Jelle Visser Frank D. Verbraak Femke H. Bouwman Retinal thickness as a potential biomarker in patients with amyloid‐proven early‐ and late‐onset Alzheimer's disease Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Retinal thickness Cortical atrophy Alzheimer's disease Neurodegeneration Biomarker |
author_facet |
Jurre denHaan Jacoba A. van deKreeke Elles Konijnenberg Mara tenKate Anouk denBraber Frederik Barkhof Bart N. vanBerckel Charlotte E. Teunissen Philip Scheltens Pieter Jelle Visser Frank D. Verbraak Femke H. Bouwman |
author_sort |
Jurre denHaan |
title |
Retinal thickness as a potential biomarker in patients with amyloid‐proven early‐ and late‐onset Alzheimer's disease |
title_short |
Retinal thickness as a potential biomarker in patients with amyloid‐proven early‐ and late‐onset Alzheimer's disease |
title_full |
Retinal thickness as a potential biomarker in patients with amyloid‐proven early‐ and late‐onset Alzheimer's disease |
title_fullStr |
Retinal thickness as a potential biomarker in patients with amyloid‐proven early‐ and late‐onset Alzheimer's disease |
title_full_unstemmed |
Retinal thickness as a potential biomarker in patients with amyloid‐proven early‐ and late‐onset Alzheimer's disease |
title_sort |
retinal thickness as a potential biomarker in patients with amyloid‐proven early‐ and late‐onset alzheimer's disease |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2019-12-01 |
description |
Abstract Introduction Retinal thickness measured with optical coherence tomography has been proposed as a noninvasive biomarker for Alzheimer's disease (AD). We therefore measured retinal thickness in well‐characterized AD and control participants, considering ophthalmological confounders. Methods We included 57 amyloid‐proven AD cases and 85 cognitively normal, amyloid‐negative controls. All subjects underwent retinal thickness measurements with spectral domain optical coherence tomography and an ophthalmological assessment to exclude ocular disease. Results Retinal thickness did not discriminate cases from controls, including stratified analyses for early‐ versus late‐onset AD. We found significant associations between macular thickness and global cortical atrophy [β −0.358; P = .01] and parietal cortical atrophy on magnetic resonance imaging [β −0.371; P < .01] in AD cases. Discussion In this study, representing the largest optical coherence tomography cohort with amyloid‐proven AD cases, we show that retinal thickness does not discriminate AD from controls, despite evident changes on clinical, neuroimaging, and CSF measures, querying the use of retinal thickness measurements as an AD biomarker. |
topic |
Retinal thickness Cortical atrophy Alzheimer's disease Neurodegeneration Biomarker |
url |
https://doi.org/10.1016/j.dadm.2019.05.002 |
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