Merkel Cell Polyomavirus T Antigens Induce Merkel Cell-Like Differentiation in GLI1-Expressing Epithelial Cells

Merkel Cell Polyomavirus T Antigens Induce Merkel Cell-Like Differentiation in GLI1-Expressing Epithelial Cells

Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by the Merkel cell polyomavirus (MCPyV). It is still under discussion, in which cells viral integration and MCC development occurs. Recently, we demonstrated that a virus-positive MCC derived from a trichoblastoma, an epithel...

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Bibliographic Details
Main Authors: Thibault Kervarrec, Mahtab Samimi, Sonja Hesbacher, Patricia Berthon, Marion Wobser, Aurélie Sallot, Bhavishya Sarma, Sophie Schweinitzer, Théo Gandon, Christophe Destrieux, Côme Pasqualin, Serge Guyétant, Antoine Touzé, Roland Houben, David Schrama
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
Merkel cell carcinoma
histogenesis
polyomavirus
ATOH1
GLI1
sonic hedgehog
Online Access:https://www.mdpi.com/2072-6694/12/7/1989

Internet

https://www.mdpi.com/2072-6694/12/7/1989

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