Study on Steroid Induced Ocular Findings in Children with Nephrotic Syndrome
Introduction: Long term use of corticosteroids in Nephrotic Syndrome (NS) is associated with ocular complications such as Posterior Subcapsular Cataract (PSC), glaucoma, increased intraocular pressure, ptosis, mydriasis, eyelid skin atrophy, keratisis, thinning of cornea and sclera, repeated hord...
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doaj-4e6d2aae8a3744fa81b472141cb4fcce2020-11-25T02:14:03ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-03-01113SC05SC0610.7860/JCDR/2017/24694.9334Study on Steroid Induced Ocular Findings in Children with Nephrotic SyndromeVijay Agrawal0Kusum Devpura1Laxmikant Mishra2Sajan Agarwal3Assistant Professor, Department of Paediatric, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India.Professor, Department of paediatric, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India.Senior Resident, Department of paediatric, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India.Senior Resident, Department of Paediatric, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India.Introduction: Long term use of corticosteroids in Nephrotic Syndrome (NS) is associated with ocular complications such as Posterior Subcapsular Cataract (PSC), glaucoma, increased intraocular pressure, ptosis, mydriasis, eyelid skin atrophy, keratisis, thinning of cornea and sclera, repeated hordeolum exacerbations. Aim: To determine ocular abnormalities in children with NS and their association with steroid dosing and duration. Materials and Methods: Hundred patients with NS in the age group of 2-18 years, with no evidence of other systemic disease, were considered for the study. Group I included cases (66) who took standard steroid regimen for first episode of NS. Group II included cases (34) who took steroid irrationally (daily basis for long time) other than standard regimen. Steroid induced ocular complications were compared in both groups after detailed ophthalmological examination. Statistical analysis was done using Statistical Package for Social Science (SPSS-20.0). Results: Ocular abnormalities were found in 12 patients out of 66 in Group I (18%) and 16 patients out of 34 patients in Group II (47%). Out of 12 patients of Group I who had ocular problems, three had myopic astigmatism, eight patients had PSC and one had temporal disc pallor. While in Group II, out of 16 patients who had ocular complications, two patients had raised intra ocular pressure and two patients had myopic astigmatism and 12 patients had posterior sub capsular cataract. The difference in mean cumulative steroid doses in both groups was statistically significant but no such difference was there between duration of steroid intake in both group. Conclusion: Our study concluded that ocular complications were more common in patients with irrationally steroid intake and cumulative steroid dose intake was also significantly higher in same patients. https://jcdr.net/articles/PDF/9334/24694__CE[Ra1]_F(RK)_PF1(P_RK)_PFA_NC_PF2(NE_SY_DK).pdfcorticosteroididiopathic nephrotic syndromeocular complications |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vijay Agrawal Kusum Devpura Laxmikant Mishra Sajan Agarwal |
spellingShingle |
Vijay Agrawal Kusum Devpura Laxmikant Mishra Sajan Agarwal Study on Steroid Induced Ocular Findings in Children with Nephrotic Syndrome Journal of Clinical and Diagnostic Research corticosteroid idiopathic nephrotic syndrome ocular complications |
author_facet |
Vijay Agrawal Kusum Devpura Laxmikant Mishra Sajan Agarwal |
author_sort |
Vijay Agrawal |
title |
Study on Steroid Induced Ocular Findings in Children with Nephrotic Syndrome |
title_short |
Study on Steroid Induced Ocular Findings in Children with Nephrotic Syndrome |
title_full |
Study on Steroid Induced Ocular Findings in Children with Nephrotic Syndrome |
title_fullStr |
Study on Steroid Induced Ocular Findings in Children with Nephrotic Syndrome |
title_full_unstemmed |
Study on Steroid Induced Ocular Findings in Children with Nephrotic Syndrome |
title_sort |
study on steroid induced ocular findings in children with nephrotic syndrome |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2017-03-01 |
description |
Introduction: Long term use of corticosteroids in Nephrotic
Syndrome (NS) is associated with ocular complications such as
Posterior Subcapsular Cataract (PSC), glaucoma, increased intraocular pressure, ptosis, mydriasis, eyelid skin atrophy, keratisis,
thinning of cornea and sclera, repeated hordeolum exacerbations.
Aim: To determine ocular abnormalities in children with NS and
their association with steroid dosing and duration.
Materials and Methods: Hundred patients with NS in the age
group of 2-18 years, with no evidence of other systemic disease,
were considered for the study. Group I included cases (66) who
took standard steroid regimen for first episode of NS. Group II
included cases (34) who took steroid irrationally (daily basis for
long time) other than standard regimen. Steroid induced ocular
complications were compared in both groups after detailed
ophthalmological examination. Statistical analysis was done
using Statistical Package for Social Science (SPSS-20.0).
Results: Ocular abnormalities were found in 12 patients out of
66 in Group I (18%) and 16 patients out of 34 patients in Group
II (47%). Out of 12 patients of Group I who had ocular problems,
three had myopic astigmatism, eight patients had PSC and one
had temporal disc pallor. While in Group II, out of 16 patients
who had ocular complications, two patients had raised intra
ocular pressure and two patients had myopic astigmatism and
12 patients had posterior sub capsular cataract. The difference
in mean cumulative steroid doses in both groups was statistically
significant but no such difference was there between duration
of steroid intake in both group.
Conclusion: Our study concluded that ocular complications
were more common in patients with irrationally steroid intake
and cumulative steroid dose intake was also significantly higher
in same patients. |
topic |
corticosteroid idiopathic nephrotic syndrome ocular complications |
url |
https://jcdr.net/articles/PDF/9334/24694__CE[Ra1]_F(RK)_PF1(P_RK)_PFA_NC_PF2(NE_SY_DK).pdf |
work_keys_str_mv |
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