Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature
Human parvovirus B19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. The different clinical outcome of the acute parvovirus B19 infection in two pediatric patients with sickle cell disease h...
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100017&lng=en&tlng=en |
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doaj-4e6dac0493a84fc8996db7f23be827402020-11-25T03:43:48ZengElsevierBrazilian Journal of Infectious Diseases1678-43911719710110.1016/j.bjid.2012.06.026S1413-86702013000100017Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literatureSvetoslav Nanev Slavov0Simone Kashima1Ana Cristina Silva-Pinto2Alberto Anastacio Amarilla3Victor Hugo Aquino4Dimas Tadeu Covas5Universidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloUniversidade de São PauloHuman parvovirus B19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. The different clinical outcome of the acute parvovirus B19 infection in two pediatric patients with sickle cell disease has been examined. One of them developed life-threatening condition requiring emergency transfusions, while the other had asymptomatic infection, diagnosed occasionally. Both cases had high viral load and identical subgenotype, indicating that the viral molecular characteristics play a minimal role in the infection outcome.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100017&lng=en&tlng=enHuman parvovirus B19Viral loadAplastic crisisSubgenotypes |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Svetoslav Nanev Slavov Simone Kashima Ana Cristina Silva-Pinto Alberto Anastacio Amarilla Victor Hugo Aquino Dimas Tadeu Covas |
| spellingShingle |
Svetoslav Nanev Slavov Simone Kashima Ana Cristina Silva-Pinto Alberto Anastacio Amarilla Victor Hugo Aquino Dimas Tadeu Covas Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature Brazilian Journal of Infectious Diseases Human parvovirus B19 Viral load Aplastic crisis Subgenotypes |
| author_facet |
Svetoslav Nanev Slavov Simone Kashima Ana Cristina Silva-Pinto Alberto Anastacio Amarilla Victor Hugo Aquino Dimas Tadeu Covas |
| author_sort |
Svetoslav Nanev Slavov |
| title |
Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature |
| title_short |
Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature |
| title_full |
Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature |
| title_fullStr |
Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature |
| title_full_unstemmed |
Molecular and clinical evaluation of the acute human parvovirus B19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature |
| title_sort |
molecular and clinical evaluation of the acute human parvovirus b19 infection: comparison of two cases in children with sickle cell disease and discussion of the literature |
| publisher |
Elsevier |
| series |
Brazilian Journal of Infectious Diseases |
| issn |
1678-4391 |
| description |
Human parvovirus B19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. The different clinical outcome of the acute parvovirus B19 infection in two pediatric patients with sickle cell disease has been examined. One of them developed life-threatening condition requiring emergency transfusions, while the other had asymptomatic infection, diagnosed occasionally. Both cases had high viral load and identical subgenotype, indicating that the viral molecular characteristics play a minimal role in the infection outcome. |
| topic |
Human parvovirus B19 Viral load Aplastic crisis Subgenotypes |
| url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100017&lng=en&tlng=en |
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