Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini)
In the present study, the coding region of the H gene was sequenced and analyzed in fourteen genera of New World primates (Alouatta, Aotus, Ateles, Brachyteles, Cacajao, Callicebus, Callithrix, Cebus, Chiropotes, Lagothrix, Leontopithecus, Pithecia, Saguinus, and Saimiri), in order to investigate th...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Sociedade Brasileira de Genética
2004-01-01
|
Series: | Genetics and Molecular Biology |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000300007 |
id |
doaj-4e6f17cd02f64d1cbcf92dc7aea15787 |
---|---|
record_format |
Article |
spelling |
doaj-4e6f17cd02f64d1cbcf92dc7aea157872020-11-25T01:25:20ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852004-01-0127334234910.1590/S1415-47572004000300007Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini)Bárbara do Nascimento BorgesMaria Lúcia HaradaIn the present study, the coding region of the H gene was sequenced and analyzed in fourteen genera of New World primates (Alouatta, Aotus, Ateles, Brachyteles, Cacajao, Callicebus, Callithrix, Cebus, Chiropotes, Lagothrix, Leontopithecus, Pithecia, Saguinus, and Saimiri), in order to investigate the evolution of the gene. The analyses revealed that this coding region contains 1,101 nucleotides, with the exception of Brachyteles, the callitrichines (Callithrix, Leontopithecus, and Saguinus) and one species of Callicebus (moloch), in which one codon was deleted. In the primates studied, the high GC content (63%), the nonrandom distribution of codons and the low evolution rate of the gene (0.513 substitutions/site/MA in the order Primates) suggest the action of a purifying type of selective pressure, confirmed by the Z-test. Our analyses did not identify mutations equivalent to those responsible for the H-deficient phenotypes found in humans, nor any other alteration that might explain the lack of expression of the gene in the erythrocytes of Neotropical monkeys. The phylogenetic trees obtained for the H gene and the distance matrix data suggest the occurrence of divergent evolution in the primates.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000300007H genemolecular evolutionpurifying selectiondivergent evolutionNew World monkeys |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bárbara do Nascimento Borges Maria Lúcia Harada |
spellingShingle |
Bárbara do Nascimento Borges Maria Lúcia Harada Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini) Genetics and Molecular Biology H gene molecular evolution purifying selection divergent evolution New World monkeys |
author_facet |
Bárbara do Nascimento Borges Maria Lúcia Harada |
author_sort |
Bárbara do Nascimento Borges |
title |
Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini) |
title_short |
Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini) |
title_full |
Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini) |
title_fullStr |
Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini) |
title_full_unstemmed |
Divergent evolution and purifying selection of the H (FUT1) gene in New World monkeys (Primates, Platyrrhini) |
title_sort |
divergent evolution and purifying selection of the h (fut1) gene in new world monkeys (primates, platyrrhini) |
publisher |
Sociedade Brasileira de Genética |
series |
Genetics and Molecular Biology |
issn |
1415-4757 1678-4685 |
publishDate |
2004-01-01 |
description |
In the present study, the coding region of the H gene was sequenced and analyzed in fourteen genera of New World primates (Alouatta, Aotus, Ateles, Brachyteles, Cacajao, Callicebus, Callithrix, Cebus, Chiropotes, Lagothrix, Leontopithecus, Pithecia, Saguinus, and Saimiri), in order to investigate the evolution of the gene. The analyses revealed that this coding region contains 1,101 nucleotides, with the exception of Brachyteles, the callitrichines (Callithrix, Leontopithecus, and Saguinus) and one species of Callicebus (moloch), in which one codon was deleted. In the primates studied, the high GC content (63%), the nonrandom distribution of codons and the low evolution rate of the gene (0.513 substitutions/site/MA in the order Primates) suggest the action of a purifying type of selective pressure, confirmed by the Z-test. Our analyses did not identify mutations equivalent to those responsible for the H-deficient phenotypes found in humans, nor any other alteration that might explain the lack of expression of the gene in the erythrocytes of Neotropical monkeys. The phylogenetic trees obtained for the H gene and the distance matrix data suggest the occurrence of divergent evolution in the primates. |
topic |
H gene molecular evolution purifying selection divergent evolution New World monkeys |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000300007 |
work_keys_str_mv |
AT barbaradonascimentoborges divergentevolutionandpurifyingselectionofthehfut1geneinnewworldmonkeysprimatesplatyrrhini AT marialuciaharada divergentevolutionandpurifyingselectionofthehfut1geneinnewworldmonkeysprimatesplatyrrhini |
_version_ |
1725114464686047232 |