Characterization of HPV DNA methylation of contiguous CpG sites by bisulfite treatment andmassively parallel sequencing- the FRAGMENT approach

Characterization of HPV DNA methylation of contiguous CpG sites by bisulfite treatment andmassively parallel sequencing- the FRAGMENT approach

Invasive cervix cancer (ICC) is the third most common malignant tumor in women and human papillomavirus 16 (HPV16) causes more than 50% of ICC. DNA methylation is a covalent modification predominantly occurring at CpG dinucleotides and increased methylation across the HPV16 genome is strongly associ...

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Bibliographic Details
Main Authors: Chang eSun, Thomas eMcAndrew, Benjamin C. Smith, Zigui eChen, Marina eFrimer, Robert D Burk
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Genetics
Subjects:
Methylation
Human papillomavirus
next generation sequencing
CpG methylation
methylation haplotypes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00150/full

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