OCT4 Silencing Triggers Its Epigenetic Repression and Impairs the Osteogenic and Adipogenic Differentiation of Mesenchymal Stromal Cells
Mechanisms mediating mesenchymal stromal/stem cells’ (MSCs) multipotency are unclear. Although the expression of the pluripotency factor OCT4 has been detected in MSCs, whether it has a functional role in adult stem cells is still controversial. We hypothesized that a physiological express...
Main Authors: | Ricardo Malvicini, Diego Santa-Cruz, Natalia Pacienza, Gustavo Yannarelli |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-07-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/20/13/3268 |
Similar Items
-
OCT4 expression mediates partial cardiomyocyte reprogramming of mesenchymal stromal cells.
by: Gustavo Yannarelli, et al.
Published: (2017-01-01) -
Metformin Promotes Osteogenic Differentiation of Adipose-Derived Stromal Cells and Exerts Pro-Osteogenic Effect Stimulating Bone Regeneration
by: Agnieszka Śmieszek, et al.
Published: (2018-11-01) -
En face OCT
by: Andre Romano, et al.
Published: (2014-04-01) -
ENCAPSULATION OF MESENCHYMAL STROMAL CELLS IN ALGINATE MICROSPHERES
by: Mazur, et al.
Published: (2016-08-01) -
Acquisition and Expansion of Adult Rat Bone Marrow Multipotent Mesenchymal Stromal Cells
by: Šulla I., et al.
Published: (2017-03-01)