COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country
Abstract On March 11th, 2020 the World Health Organization declared COVID-19 a global pandemic. The infection, transmitted by 2019 novel coronavirus (2019-nCov), was first discovered in December 2019, in Wuhan, Hubei Province, and then rapidly spread worldwide. Italy was early and severely involved,...
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doaj-4e8516c21c8c4154a7d9cefba009cea52020-11-25T03:49:29ZengBMCPediatric Rheumatology Online Journal1546-00962020-04-011811710.1186/s12969-020-00422-zCOVID-19 and what pediatric rheumatologists should know: a review from a highly affected countryFrancesco Licciardi0Teresa Giani1Letizia Baldini2Ennio Giulio Favalli3Roberto Caporali4Rolando Cimaz5Division of Pediatric Immunology and Rheumatology, Department of Public Health and Pediatrics, Regina Margherita Children Hospital, University of TurinAOU MeyerDivision of Pediatric Immunology and Rheumatology, Department of Public Health and Pediatrics, Regina Margherita Children Hospital, University of TurinDivision of Clinical Rheumatology, ASST Gaetano Pini-CTO InstituteDivision of Clinical Rheumatology, ASST Gaetano Pini-CTO InstituteDivision of Clinical Rheumatology, ASST Gaetano Pini-CTO InstituteAbstract On March 11th, 2020 the World Health Organization declared COVID-19 a global pandemic. The infection, transmitted by 2019 novel coronavirus (2019-nCov), was first discovered in December 2019, in Wuhan, Hubei Province, and then rapidly spread worldwide. Italy was early and severely involved, with a critical spread of the infection and a very high number of victims. Person-to-person spread mainly occurs via respiratory droplets and contact. The median incubation period is 5 days. The spectrum of respiratory symptoms may range from mild to severe, strictly depending on the age of the patient and the underlying comorbidities. In children COVID-19 related disease is less frequent and less aggressive. In Italy 1% of positive cases are under 18 years of age, and no deaths have been recorded before 29 years of age. For patients affected by rheumatic disease, despite the concerns related to the imbalance of their immune response and the effect of immunosuppressive treatments, there are still few data to understand the real consequences of this infection. Major scientific societies have issued recommendations to help rheumatologists in caring their patients. Interestingly, some of the drugs mostly used by rheumatologists appear to be promising in critical COVID-19 infected patients, where the hyperinflammation and cytokine storm seem to drive to the multiorgan failure. Pediatric rheumatologists are expected to play a supporting role in this new front of COVID-19 pandemic, both as general pediatricians treating infected children, and as rheumatologists taking care of their rheumatic patients, as well as offering their experience in the possible alternative use of immunomodulatory drugs.http://link.springer.com/article/10.1186/s12969-020-00422-z2019-nCoVSARS-CoV-2COVID-19ChildrenRespiratory syndromeItaly |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesco Licciardi Teresa Giani Letizia Baldini Ennio Giulio Favalli Roberto Caporali Rolando Cimaz |
spellingShingle |
Francesco Licciardi Teresa Giani Letizia Baldini Ennio Giulio Favalli Roberto Caporali Rolando Cimaz COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country Pediatric Rheumatology Online Journal 2019-nCoV SARS-CoV-2 COVID-19 Children Respiratory syndrome Italy |
author_facet |
Francesco Licciardi Teresa Giani Letizia Baldini Ennio Giulio Favalli Roberto Caporali Rolando Cimaz |
author_sort |
Francesco Licciardi |
title |
COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country |
title_short |
COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country |
title_full |
COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country |
title_fullStr |
COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country |
title_full_unstemmed |
COVID-19 and what pediatric rheumatologists should know: a review from a highly affected country |
title_sort |
covid-19 and what pediatric rheumatologists should know: a review from a highly affected country |
publisher |
BMC |
series |
Pediatric Rheumatology Online Journal |
issn |
1546-0096 |
publishDate |
2020-04-01 |
description |
Abstract On March 11th, 2020 the World Health Organization declared COVID-19 a global pandemic. The infection, transmitted by 2019 novel coronavirus (2019-nCov), was first discovered in December 2019, in Wuhan, Hubei Province, and then rapidly spread worldwide. Italy was early and severely involved, with a critical spread of the infection and a very high number of victims. Person-to-person spread mainly occurs via respiratory droplets and contact. The median incubation period is 5 days. The spectrum of respiratory symptoms may range from mild to severe, strictly depending on the age of the patient and the underlying comorbidities. In children COVID-19 related disease is less frequent and less aggressive. In Italy 1% of positive cases are under 18 years of age, and no deaths have been recorded before 29 years of age. For patients affected by rheumatic disease, despite the concerns related to the imbalance of their immune response and the effect of immunosuppressive treatments, there are still few data to understand the real consequences of this infection. Major scientific societies have issued recommendations to help rheumatologists in caring their patients. Interestingly, some of the drugs mostly used by rheumatologists appear to be promising in critical COVID-19 infected patients, where the hyperinflammation and cytokine storm seem to drive to the multiorgan failure. Pediatric rheumatologists are expected to play a supporting role in this new front of COVID-19 pandemic, both as general pediatricians treating infected children, and as rheumatologists taking care of their rheumatic patients, as well as offering their experience in the possible alternative use of immunomodulatory drugs. |
topic |
2019-nCoV SARS-CoV-2 COVID-19 Children Respiratory syndrome Italy |
url |
http://link.springer.com/article/10.1186/s12969-020-00422-z |
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