Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease
The genetic basis of festination, a common motor symptom in Parkinson’s disease (PD), remains unclear. Since polymorphism in the alpha-synuclein (SNCA) gene is associated with PD phenotype, we examined whether such polymorphism is also associated with festination. SNCA polymorphisms rs11931074 and r...
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Online Access: | http://dx.doi.org/10.1155/2017/3176805 |
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doaj-4e881a97e3074101b83f289d121d0d592020-11-24T23:25:37ZengHindawi LimitedParkinson's Disease2090-80832042-00802017-01-01201710.1155/2017/31768053176805Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s DiseaseJinhua Zheng0Xinglong Yang1Quanzhen Zhao2Sijia Tian3Hongyan Huang4Yalan Chen5Yanming Xu6Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province 610041, ChinaDepartment of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province 610041, ChinaThe genetic basis of festination, a common motor symptom in Parkinson’s disease (PD), remains unclear. Since polymorphism in the alpha-synuclein (SNCA) gene is associated with PD phenotype, we examined whether such polymorphism is also associated with festination. SNCA polymorphisms rs11931074 and rs894278 were genotyped in a consecutive series of 258 patients with PD, of whom 122 (47.3%) suffered festination. Univariate analysis revealed significant differences in genotype and minor allele frequencies at rs11931074 or rs894278 between patients with festination and those without it (all p<0.05). Based on logistic regression, a GG or GT genotype at rs11931074 was associated with higher risk of festination among patients with PD (OR 2.077, 95% CI 1.111–3.883, p=0.022), as was the TT genotype at rs894278 (OR 2.271, 95% CI 1.246–4.139, p=0.007). Therefore, we conclude that festination is associated with polymorphism at rs11931074 or rs894278 among patients with PD.http://dx.doi.org/10.1155/2017/3176805 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jinhua Zheng Xinglong Yang Quanzhen Zhao Sijia Tian Hongyan Huang Yalan Chen Yanming Xu |
spellingShingle |
Jinhua Zheng Xinglong Yang Quanzhen Zhao Sijia Tian Hongyan Huang Yalan Chen Yanming Xu Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease Parkinson's Disease |
author_facet |
Jinhua Zheng Xinglong Yang Quanzhen Zhao Sijia Tian Hongyan Huang Yalan Chen Yanming Xu |
author_sort |
Jinhua Zheng |
title |
Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease |
title_short |
Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease |
title_full |
Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease |
title_fullStr |
Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease |
title_full_unstemmed |
Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease |
title_sort |
festination correlates with snca polymorphism in chinese patients with parkinson’s disease |
publisher |
Hindawi Limited |
series |
Parkinson's Disease |
issn |
2090-8083 2042-0080 |
publishDate |
2017-01-01 |
description |
The genetic basis of festination, a common motor symptom in Parkinson’s disease (PD), remains unclear. Since polymorphism in the alpha-synuclein (SNCA) gene is associated with PD phenotype, we examined whether such polymorphism is also associated with festination. SNCA polymorphisms rs11931074 and rs894278 were genotyped in a consecutive series of 258 patients with PD, of whom 122 (47.3%) suffered festination. Univariate analysis revealed significant differences in genotype and minor allele frequencies at rs11931074 or rs894278 between patients with festination and those without it (all p<0.05). Based on logistic regression, a GG or GT genotype at rs11931074 was associated with higher risk of festination among patients with PD (OR 2.077, 95% CI 1.111–3.883, p=0.022), as was the TT genotype at rs894278 (OR 2.271, 95% CI 1.246–4.139, p=0.007). Therefore, we conclude that festination is associated with polymorphism at rs11931074 or rs894278 among patients with PD. |
url |
http://dx.doi.org/10.1155/2017/3176805 |
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