Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report

Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report

We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resi...

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Main Authors: Rodrigo Vettorato, Daiane Heidrich, Fernanda Fraga, Amanda Carvalho Ribeiro, Danielle Machado Pagani, Carina Timotheo, Tais Guarienti Amaro, Gerson Vettorato, Maria Lúcia Scroferneker
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Medical Mycology Case Reports
Subjects:
Sporotrichosis
Sporothrix schenckii
Senso stricto
Itraconazole
Terbinafine
Antifungal susceptibility
Online Access:http://www.sciencedirect.com/science/article/pii/S2211753917300532
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spelling doaj-4e8870ae5e1649cf9ab02dbb5e72d77e2020-11-25T03:40:38ZengElsevierMedical Mycology Case Reports2211-75392018-03-0119C182010.1016/j.mmcr.2017.10.001Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case reportRodrigo Vettorato0Daiane Heidrich1Fernanda Fraga2Amanda Carvalho Ribeiro3Danielle Machado Pagani4Carina Timotheo5Tais Guarienti Amaro6Gerson Vettorato7Maria Lúcia Scroferneker8Postgraduate Program in Medicine, Medical Sciences, Universidade Federal do Rio Grande do Sul, BrazilPostgraduate Program in Medicine, Medical Sciences, Universidade Federal do Rio Grande do Sul, BrazilDepartment of Microbiology, Immunology and Parasitology, ICBS, Universidade Federal do Rio Grande do Sul, BrazilPostgraduate Program in Agricultural and Environmental Microbiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilDepartment of Microbiology, Immunology and Parasitology, ICBS, Universidade Federal do Rio Grande do Sul, BrazilDepartment of Microbiology, Immunology and Parasitology, ICBS, Universidade Federal do Rio Grande do Sul, BrazilDermatology Service of Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre, BrazilDermatology Service of Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre, BrazilPostgraduate Program in Medicine, Medical Sciences, Universidade Federal do Rio Grande do Sul, BrazilWe report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four monthshttp://www.sciencedirect.com/science/article/pii/S2211753917300532SporotrichosisSporothrix schenckiiSenso strictoItraconazoleTerbinafineAntifungal susceptibility
collection DOAJ
language English
format Article
sources DOAJ
author Rodrigo Vettorato
Daiane Heidrich
Fernanda Fraga
Amanda Carvalho Ribeiro
Danielle Machado Pagani
Carina Timotheo
Tais Guarienti Amaro
Gerson Vettorato
Maria Lúcia Scroferneker
spellingShingle Rodrigo Vettorato
Daiane Heidrich
Fernanda Fraga
Amanda Carvalho Ribeiro
Danielle Machado Pagani
Carina Timotheo
Tais Guarienti Amaro
Gerson Vettorato
Maria Lúcia Scroferneker
Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
Medical Mycology Case Reports
Sporotrichosis
Sporothrix schenckii
Senso stricto
Itraconazole
Terbinafine
Antifungal susceptibility
author_facet Rodrigo Vettorato
Daiane Heidrich
Fernanda Fraga
Amanda Carvalho Ribeiro
Danielle Machado Pagani
Carina Timotheo
Tais Guarienti Amaro
Gerson Vettorato
Maria Lúcia Scroferneker
author_sort Rodrigo Vettorato
title Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title_short Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title_full Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title_fullStr Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title_full_unstemmed Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: Case report
title_sort sporotrichosis by sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: case report
publisher Elsevier
series Medical Mycology Case Reports
issn 2211-7539
publishDate 2018-03-01
description We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months
topic Sporotrichosis
Sporothrix schenckii
Senso stricto
Itraconazole
Terbinafine
Antifungal susceptibility
url http://www.sciencedirect.com/science/article/pii/S2211753917300532
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