Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae

Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae

The amidotransferase MurT/GatD complex catalyzes peptidoglycan precursor amidation in some Gram-positive bacteria. Here the authors present the crystal structure of the Streptococcus pneumoniae MurT/GatD complex and provide mechanistic insights, which are of interest for drug development.

Bibliographic Details
Main Authors: Cécile Morlot, Daniel Straume, Katharina Peters, Olav A. Hegnar, Nolwenn Simon, Anne-Marie Villard, Carlos Contreras-Martel, Francisco Leisico, Eefjan Breukink, Christine Gravier-Pelletier, Laurent Le Corre, Waldemar Vollmer, Nicolas Pietrancosta, Leiv Sigve Håvarstein, André Zapun
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05602-w
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spelling doaj-4e8f7d6353d84e29a4d53b28f4a9d9e82021-05-11T09:46:13ZengNature Publishing GroupNature Communications2041-17232018-08-019111210.1038/s41467-018-05602-wStructure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniaeCécile Morlot0Daniel Straume1Katharina Peters2Olav A. Hegnar3Nolwenn Simon4Anne-Marie Villard5Carlos Contreras-Martel6Francisco Leisico7Eefjan Breukink8Christine Gravier-Pelletier9Laurent Le Corre10Waldemar Vollmer11Nicolas Pietrancosta12Leiv Sigve Håvarstein13André Zapun14Université Grenoble Alpes, CNRS, CEAFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesCentre for Bacterial Cell Biology, Institute for Cell and Molecular Bioscience, Newcastle UniversityFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesUniversité Grenoble Alpes, CNRS, CEAUniversité Grenoble Alpes, CNRS, CEAUniversité Grenoble Alpes, CNRS, CEADepartamento de Química, Universidade Nova de LisboaMembrane Biochemistry and Biophysics, Department of Chemistry, Faculty of Science, Utrecht UniversityUniversité Paris Descartes, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques UMR 8601 CNRS, Sorbonne Paris Cité (USPC)Université Paris Descartes, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques UMR 8601 CNRS, Sorbonne Paris Cité (USPC)Centre for Bacterial Cell Biology, Institute for Cell and Molecular Bioscience, Newcastle UniversityUniversité Paris Descartes, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques UMR 8601 CNRS, Sorbonne Paris Cité (USPC)Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life SciencesUniversité Grenoble Alpes, CNRS, CEAThe amidotransferase MurT/GatD complex catalyzes peptidoglycan precursor amidation in some Gram-positive bacteria. Here the authors present the crystal structure of the Streptococcus pneumoniae MurT/GatD complex and provide mechanistic insights, which are of interest for drug development.https://doi.org/10.1038/s41467-018-05602-w
collection DOAJ
language English
format Article
sources DOAJ
author Cécile Morlot
Daniel Straume
Katharina Peters
Olav A. Hegnar
Nolwenn Simon
Anne-Marie Villard
Carlos Contreras-Martel
Francisco Leisico
Eefjan Breukink
Christine Gravier-Pelletier
Laurent Le Corre
Waldemar Vollmer
Nicolas Pietrancosta
Leiv Sigve Håvarstein
André Zapun
spellingShingle Cécile Morlot
Daniel Straume
Katharina Peters
Olav A. Hegnar
Nolwenn Simon
Anne-Marie Villard
Carlos Contreras-Martel
Francisco Leisico
Eefjan Breukink
Christine Gravier-Pelletier
Laurent Le Corre
Waldemar Vollmer
Nicolas Pietrancosta
Leiv Sigve Håvarstein
André Zapun
Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
Nature Communications
author_facet Cécile Morlot
Daniel Straume
Katharina Peters
Olav A. Hegnar
Nolwenn Simon
Anne-Marie Villard
Carlos Contreras-Martel
Francisco Leisico
Eefjan Breukink
Christine Gravier-Pelletier
Laurent Le Corre
Waldemar Vollmer
Nicolas Pietrancosta
Leiv Sigve Håvarstein
André Zapun
author_sort Cécile Morlot
title Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
title_short Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
title_full Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
title_fullStr Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
title_full_unstemmed Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae
title_sort structure of the essential peptidoglycan amidotransferase murt/gatd complex from streptococcus pneumoniae
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description The amidotransferase MurT/GatD complex catalyzes peptidoglycan precursor amidation in some Gram-positive bacteria. Here the authors present the crystal structure of the Streptococcus pneumoniae MurT/GatD complex and provide mechanistic insights, which are of interest for drug development.
url https://doi.org/10.1038/s41467-018-05602-w
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