Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from <i>Aerides multiflora</i> and Their <i>α</i>-Glucosidase Inhibitory Activity

Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from <i>Aerides multiflora</i> and Their <i>α</i>-Glucosidase Inhibitory Activity

A phytochemical investigation on the whole plants of <i>Aerides multiflora</i> revealed the presence of three new biphenanthrene derivatives named aerimultins A–C (<b>1</b>–<b>3</b>) and a new natural phenylpropanoid ester dihydrosinapyl dihydroferulate (<b>...

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Main Authors: May Thazin Thant, Boonchoo Sritularak, Nutputsorn Chatsumpun, Wanwimon Mekboonsonglarp, Yanyong Punpreuk, Kittisak Likhitwitayawuid
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Plants
Subjects:
<i>Aerides multiflora</i>
Orchidaceae
<i>α</i>-glucosidase inhibition
biphenanthrene derivatives
phenylpropanoid ester
Online Access:https://www.mdpi.com/2223-7747/10/2/385
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spelling doaj-4e92dc965f374d02b6a10e0beac8d58c2021-02-18T00:04:55ZengMDPI AGPlants2223-77472021-02-011038538510.3390/plants10020385Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from <i>Aerides multiflora</i> and Their <i>α</i>-Glucosidase Inhibitory ActivityMay Thazin Thant0Boonchoo Sritularak1Nutputsorn Chatsumpun2Wanwimon Mekboonsonglarp3Yanyong Punpreuk4Kittisak Likhitwitayawuid5Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandScientific and Technological Research Equipment Centre, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Agriculture, Bangkok 10900, ThailandDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, ThailandA phytochemical investigation on the whole plants of <i>Aerides multiflora</i> revealed the presence of three new biphenanthrene derivatives named aerimultins A–C (<b>1</b>–<b>3</b>) and a new natural phenylpropanoid ester dihydrosinapyl dihydroferulate (<b>4</b>), together with six known compounds (<b>5–10</b>). The structures of the new compounds were elucidated by analysis of their spectroscopic data. All of the isolates were evaluated for their <i>a</i>-glucosidase inhibitory activity. Aerimultin C (<b>3</b>) showed the most potent activity. The other compounds, except for compound <b>4</b>, also exhibited stronger activity than the positive control acarbose. Compound <b>3</b> showed non-competitive inhibition of the enzyme as determined from a Lineweaver–Burk plot. This study is the first phytochemical and biological investigation of <i>A. multiflora</i>.https://www.mdpi.com/2223-7747/10/2/385<i>Aerides multiflora</i>Orchidaceae<i>α</i>-glucosidase inhibitionbiphenanthrene derivativesphenylpropanoid ester
collection DOAJ
language English
format Article
sources DOAJ
author May Thazin Thant
Boonchoo Sritularak
Nutputsorn Chatsumpun
Wanwimon Mekboonsonglarp
Yanyong Punpreuk
Kittisak Likhitwitayawuid
spellingShingle May Thazin Thant
Boonchoo Sritularak
Nutputsorn Chatsumpun
Wanwimon Mekboonsonglarp
Yanyong Punpreuk
Kittisak Likhitwitayawuid
Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from <i>Aerides multiflora</i> and Their <i>α</i>-Glucosidase Inhibitory Activity
Plants
<i>Aerides multiflora</i>
Orchidaceae
<i>α</i>-glucosidase inhibition
biphenanthrene derivatives
phenylpropanoid ester
author_facet May Thazin Thant
Boonchoo Sritularak
Nutputsorn Chatsumpun
Wanwimon Mekboonsonglarp
Yanyong Punpreuk
Kittisak Likhitwitayawuid
author_sort May Thazin Thant
title Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from <i>Aerides multiflora</i> and Their <i>α</i>-Glucosidase Inhibitory Activity
title_short Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from <i>Aerides multiflora</i> and Their <i>α</i>-Glucosidase Inhibitory Activity
title_full Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from <i>Aerides multiflora</i> and Their <i>α</i>-Glucosidase Inhibitory Activity
title_fullStr Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from <i>Aerides multiflora</i> and Their <i>α</i>-Glucosidase Inhibitory Activity
title_full_unstemmed Three Novel Biphenanthrene Derivatives and a New Phenylpropanoid Ester from <i>Aerides multiflora</i> and Their <i>α</i>-Glucosidase Inhibitory Activity
title_sort three novel biphenanthrene derivatives and a new phenylpropanoid ester from <i>aerides multiflora</i> and their <i>α</i>-glucosidase inhibitory activity
publisher MDPI AG
series Plants
issn 2223-7747
publishDate 2021-02-01
description A phytochemical investigation on the whole plants of <i>Aerides multiflora</i> revealed the presence of three new biphenanthrene derivatives named aerimultins A–C (<b>1</b>–<b>3</b>) and a new natural phenylpropanoid ester dihydrosinapyl dihydroferulate (<b>4</b>), together with six known compounds (<b>5–10</b>). The structures of the new compounds were elucidated by analysis of their spectroscopic data. All of the isolates were evaluated for their <i>a</i>-glucosidase inhibitory activity. Aerimultin C (<b>3</b>) showed the most potent activity. The other compounds, except for compound <b>4</b>, also exhibited stronger activity than the positive control acarbose. Compound <b>3</b> showed non-competitive inhibition of the enzyme as determined from a Lineweaver–Burk plot. This study is the first phytochemical and biological investigation of <i>A. multiflora</i>.
topic <i>Aerides multiflora</i>
Orchidaceae
<i>α</i>-glucosidase inhibition
biphenanthrene derivatives
phenylpropanoid ester
url https://www.mdpi.com/2223-7747/10/2/385
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