Coronary plaque property evaluation by coronary CTA and its correlation with inflammatory molecules and MMPs/TIMPs
Objective: To study the evaluation value of coronary CTA for coronary plaque properties and its correlation with inflammatory molecules and MMPs/TIMPs. Methods: Patients who were diagnosed with acute coronary syndrome in Renmin Hospital of Wuhan University between August 2014 and December 2016 we...
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doaj-4e9d35792ea449feb670fa6dd5073c412020-11-25T00:47:25ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372017-11-0123213437Coronary plaque property evaluation by coronary CTA and its correlation with inflammatory molecules and MMPs/TIMPsWen-Bing Yang0Yun-Fei Zha1Zhao-Hui Yang2Dong Xing3Ren-Jie Yang4Radiology Department, Renmin Hospital of Wuhan University in Hubei Province, Wuhan City, Hubei Province, 430060Radiology Department, Renmin Hospital of Wuhan University in Hubei Province, Wuhan City, Hubei Province, 430060Radiology Department, Renmin Hospital of Wuhan University in Hubei Province, Wuhan City, Hubei Province, 430060Radiology Department, Renmin Hospital of Wuhan University in Hubei Province, Wuhan City, Hubei Province, 430060Radiology Department, Renmin Hospital of Wuhan University in Hubei Province, Wuhan City, Hubei Province, 430060Objective: To study the evaluation value of coronary CTA for coronary plaque properties and its correlation with inflammatory molecules and MMPs/TIMPs. Methods: Patients who were diagnosed with acute coronary syndrome in Renmin Hospital of Wuhan University between August 2014 and December 2016 were selected as the ACS group of the research, patients who were diagnosed with stable angina pectoris were selected as the SAP group of the research, and healthy subjects who received physical examination during the same period were selected as the control group of the research. Coronary CTA was done to determine the coronary plaque properties of ACS group, and serum was collected from the three groups of subjects to determine the contents of inflammatory molecules and MMPs/TIMPs collagen metabolites. Results: Serum MIP-1α, MCP-1, sFGL-2, sCD14, CXCL5, I-CTP, III-CTP and EMMPRIN contents of ACS group and SAP group were higher than those of control group while TIMP1, TIMP2 contents were lower than those of control group; serum MIP-1α, MCP-1, sFGL-2, sCD14, CXCL5, I-CTP, III-CTP and EMMPRIN contents of ACS group were higher than those of SAP group while TIMP1 and TIMP2 contents were lower than those of SAP group. Serum MIP-1α, MCP-1, sFGL-2, sCD14, CXCL5, I-CTP, III-CTP and EMMPRIN contents of ACS patients with soft plaque and fibrous plaque were higher than those of ACS patients with calcified plaque while TIMP1 and TIMP2 contents were lower than those of ACS patients with calcified plaque; serum MIP-1α, MCP-1, sFGL-2, sCD14, CXCL5, I-CTP, III-CTP and EMMPRIN contents of ACS patients with soft plaque were higher than those of ACS patients with fibrous plaque while TIMP1, TIMP2 contents were lower than those of ACS patients with fibrous plaque. Conclusion: The coronary plaque property evaluation by coronary CTA is closely related to the changes of inflammatory response and MMPs/TIMPs collagen metabolism.http://www.hnykdxxb.com/PDF/201721/09.pdfCoronary CTACoronary atherosclerosisInflammatory responseCollagen metabolism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wen-Bing Yang Yun-Fei Zha Zhao-Hui Yang Dong Xing Ren-Jie Yang |
spellingShingle |
Wen-Bing Yang Yun-Fei Zha Zhao-Hui Yang Dong Xing Ren-Jie Yang Coronary plaque property evaluation by coronary CTA and its correlation with inflammatory molecules and MMPs/TIMPs Journal of Hainan Medical University Coronary CTA Coronary atherosclerosis Inflammatory response Collagen metabolism |
author_facet |
Wen-Bing Yang Yun-Fei Zha Zhao-Hui Yang Dong Xing Ren-Jie Yang |
author_sort |
Wen-Bing Yang |
title |
Coronary plaque property evaluation by coronary CTA and its correlation with inflammatory molecules and MMPs/TIMPs |
title_short |
Coronary plaque property evaluation by coronary CTA and its correlation with inflammatory molecules and MMPs/TIMPs |
title_full |
Coronary plaque property evaluation by coronary CTA and its correlation with inflammatory molecules and MMPs/TIMPs |
title_fullStr |
Coronary plaque property evaluation by coronary CTA and its correlation with inflammatory molecules and MMPs/TIMPs |
title_full_unstemmed |
Coronary plaque property evaluation by coronary CTA and its correlation with inflammatory molecules and MMPs/TIMPs |
title_sort |
coronary plaque property evaluation by coronary cta and its correlation with inflammatory molecules and mmps/timps |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2017-11-01 |
description |
Objective: To study the evaluation value of coronary CTA for coronary plaque properties and
its correlation with inflammatory molecules and MMPs/TIMPs. Methods: Patients who were
diagnosed with acute coronary syndrome in Renmin Hospital of Wuhan University between
August 2014 and December 2016 were selected as the ACS group of the research, patients who
were diagnosed with stable angina pectoris were selected as the SAP group of the research,
and healthy subjects who received physical examination during the same period were selected
as the control group of the research. Coronary CTA was done to determine the coronary
plaque properties of ACS group, and serum was collected from the three groups of subjects to
determine the contents of inflammatory molecules and MMPs/TIMPs collagen metabolites.
Results: Serum MIP-1α, MCP-1, sFGL-2, sCD14, CXCL5, I-CTP, III-CTP and EMMPRIN
contents of ACS group and SAP group were higher than those of control group while TIMP1,
TIMP2 contents were lower than those of control group; serum MIP-1α, MCP-1, sFGL-2,
sCD14, CXCL5, I-CTP, III-CTP and EMMPRIN contents of ACS group were higher than
those of SAP group while TIMP1 and TIMP2 contents were lower than those of SAP group.
Serum MIP-1α, MCP-1, sFGL-2, sCD14, CXCL5, I-CTP, III-CTP and EMMPRIN contents
of ACS patients with soft plaque and fibrous plaque were higher than those of ACS patients
with calcified plaque while TIMP1 and TIMP2 contents were lower than those of ACS patients
with calcified plaque; serum MIP-1α, MCP-1, sFGL-2, sCD14, CXCL5, I-CTP, III-CTP and
EMMPRIN contents of ACS patients with soft plaque were higher than those of ACS patients
with fibrous plaque while TIMP1, TIMP2 contents were lower than those of ACS patients
with fibrous plaque. Conclusion: The coronary plaque property evaluation by coronary
CTA is closely related to the changes of inflammatory response and MMPs/TIMPs collagen
metabolism. |
topic |
Coronary CTA Coronary atherosclerosis Inflammatory response Collagen metabolism |
url |
http://www.hnykdxxb.com/PDF/201721/09.pdf |
work_keys_str_mv |
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