Biofilm Inactivation using Photodynamic Therapy in Dentistry: a review of literature
Introduction: Photodynamic therapy (PDT) is a therapy involving light and a photosensitising chemical substance, used in conjunction with molecular oxygen in order to elicit cell death (photo-toxicity) and thus ability to kill microbial cells, including bacteria, fungi and viruses. Photodynamic ther...
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doaj-4eaaa85fb97e401ba01f74bab21aafe32020-11-25T03:37:43ZengRomanian Association of Balneology, Editura BalnearaBalneo Research Journal2069-75972069-76192020-09-0111327928710.12680/balneo.2020.353Biofilm Inactivation using Photodynamic Therapy in Dentistry: a review of literatureTIȘLER Corina-Elena0BADEA Mîndra-Eugenia1BUDURU Smaranda2KUI Andreea3FLORIA Mihaela4POPESCU Ștefan5MITARIU Mihai6NEGUCIOIU Marius71. Prosthodontic Department, "Iuliu Haţieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania2. Prevention in Dentistry Department, "Iuliu Haţieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania1. Prosthodontic Department, "Iuliu Haţieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania1. Prosthodontic Department, "Iuliu Haţieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania1. Prosthodontic Department, "Iuliu Haţieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania1. Prosthodontic Department, "Iuliu Haţieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania3. “Lucian Blaga” University, Sibiu1. Prosthodontic Department, "Iuliu Haţieganu“ University of Medicine and Pharmacy, Cluj-Napoca, RomaniaIntroduction: Photodynamic therapy (PDT) is a therapy involving light and a photosensitising chemical substance, used in conjunction with molecular oxygen in order to elicit cell death (photo-toxicity) and thus ability to kill microbial cells, including bacteria, fungi and viruses. Photodynamic therapy is an alternative method of biofilm disruption and it is considered a new way of microorganism inactivation. It is also an additional procedure to reduce the infection rate in patients, caused by the increasing antimicrobials resistance of bacteria. The aim of this literature review was to evaluate the specific effects and the antibacterial effectiveness of photodynamic therapy using different types of photosensitizers (Erythrosine, Rose Bengal, Toluidine blue, Methylene blue, Ozone, Riboflavin, Curcumin, Chlorhexidine, SAPYR) and a visible light of a specific wavelength for each photosensitizer and to reveal the applications of PDT in periodontics, endodontics, prosthodontics and dental caries. Methods: A research of literature was performed in an attempt to find all the articles published on this topic in the last 10 years. The articles was searched by using a certain combination of different keywords (photodynamic therapy ) and (diode laser ) and (teeth) in PubMed database. Results: A total number of 83 articles were found. After applying inclusion and exclusion criteria, 35 articles were taken into consideration for our study and among them 4 were a manuscript, 3 was a review of literature, 1 was an in vivo evaluation and 27 were in vitro studies. Conclusion: Considering that none of the disinfection methods can completely remove the biofilm, PDT is a therapeutic tool complementary to conventional disinfection, with great applicability in dentistry. PDT showed significantly efficacy in reduction of biofilms. Exposure to light in the presence of a photosensitizing chemical substance helps in the reduction of microbes and the protocols could be recommended for clinical usage, but only together with ‘classic ‘ disinfection.http://bioclima.ro/Balneo353.pdfphotodynamicpdtbiofilmphotosensitizeroralantimicrobial therapylight |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
TIȘLER Corina-Elena BADEA Mîndra-Eugenia BUDURU Smaranda KUI Andreea FLORIA Mihaela POPESCU Ștefan MITARIU Mihai NEGUCIOIU Marius |
spellingShingle |
TIȘLER Corina-Elena BADEA Mîndra-Eugenia BUDURU Smaranda KUI Andreea FLORIA Mihaela POPESCU Ștefan MITARIU Mihai NEGUCIOIU Marius Biofilm Inactivation using Photodynamic Therapy in Dentistry: a review of literature Balneo Research Journal photodynamic pdt biofilm photosensitizer oral antimicrobial therapy light |
author_facet |
TIȘLER Corina-Elena BADEA Mîndra-Eugenia BUDURU Smaranda KUI Andreea FLORIA Mihaela POPESCU Ștefan MITARIU Mihai NEGUCIOIU Marius |
author_sort |
TIȘLER Corina-Elena |
title |
Biofilm Inactivation using Photodynamic Therapy in Dentistry: a review of literature |
title_short |
Biofilm Inactivation using Photodynamic Therapy in Dentistry: a review of literature |
title_full |
Biofilm Inactivation using Photodynamic Therapy in Dentistry: a review of literature |
title_fullStr |
Biofilm Inactivation using Photodynamic Therapy in Dentistry: a review of literature |
title_full_unstemmed |
Biofilm Inactivation using Photodynamic Therapy in Dentistry: a review of literature |
title_sort |
biofilm inactivation using photodynamic therapy in dentistry: a review of literature |
publisher |
Romanian Association of Balneology, Editura Balneara |
series |
Balneo Research Journal |
issn |
2069-7597 2069-7619 |
publishDate |
2020-09-01 |
description |
Introduction: Photodynamic therapy (PDT) is a therapy involving light and a photosensitising chemical substance, used in conjunction with molecular oxygen in order to elicit cell death (photo-toxicity) and thus ability to kill microbial cells, including bacteria, fungi and viruses. Photodynamic therapy is an alternative method of biofilm disruption and it is considered a new way of microorganism inactivation. It is also an additional procedure to reduce the infection rate in patients, caused by the increasing antimicrobials resistance of bacteria. The aim of this literature review was to evaluate the specific effects and the antibacterial effectiveness of photodynamic therapy using different types of photosensitizers (Erythrosine, Rose Bengal, Toluidine blue, Methylene blue, Ozone, Riboflavin, Curcumin, Chlorhexidine, SAPYR) and a visible light of a specific wavelength for each photosensitizer and to reveal the applications of PDT in periodontics, endodontics, prosthodontics and dental caries. Methods: A research of literature was performed in an attempt to find all the articles published on this topic in the last 10 years. The articles was searched by using a certain combination of different keywords (photodynamic therapy ) and (diode laser ) and (teeth) in PubMed database. Results: A total number of 83 articles were found. After applying inclusion and exclusion criteria, 35 articles were taken into consideration for our study and among them 4 were a manuscript, 3 was a review of literature, 1 was an in vivo evaluation and 27 were in vitro studies. Conclusion: Considering that none of the disinfection methods can completely remove the biofilm, PDT is a therapeutic tool complementary to conventional disinfection, with great applicability in dentistry. PDT showed significantly efficacy in reduction of biofilms. Exposure to light in the presence of a photosensitizing chemical substance helps in the reduction of microbes and the protocols could be recommended for clinical usage, but only together with ‘classic ‘ disinfection. |
topic |
photodynamic pdt biofilm photosensitizer oral antimicrobial therapy light |
url |
http://bioclima.ro/Balneo353.pdf |
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