Hepatitis B Virus Cure: Targets and Future Therapies
Chronic hepatitis B virus (HBV) infection is a major global health problem. It can cause progressive liver fibrosis leading to cirrhosis with end-stage liver disease, and a markedly increased risk of hepatocellular carcinoma. In the last two decades, substantial progress has been made in the treatme...
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doaj-4eae2f79f0554034bc4ba2c5904733b02020-12-29T00:03:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-012221321310.3390/ijms22010213Hepatitis B Virus Cure: Targets and Future TherapiesHye Won Lee0Jae Seung Lee1Sang Hoon Ahn2Department of Internal Medicine, College of Medicine, Yonsei University, Seoul 03722, KoreaDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul 03722, KoreaDepartment of Internal Medicine, College of Medicine, Yonsei University, Seoul 03722, KoreaChronic hepatitis B virus (HBV) infection is a major global health problem. It can cause progressive liver fibrosis leading to cirrhosis with end-stage liver disease, and a markedly increased risk of hepatocellular carcinoma. In the last two decades, substantial progress has been made in the treatment of chronic hepatitis, B. However, HBV is often reactivated after stopping nucloes(t)ide analogues because antivirals alone do not directly target covalently closed circular DNA, which is the template for all viral RNAs. Therefore, although currently available antiviral therapies achieve suppression of HBV replication in the majority of patients, hepatitis B surface antigen (HBsAg) loss and seroconversion is rarely achieved despite long-term antiviral treatment (HBsAg loss of less than 10% in 5 years). Various clinical trials of agents that interrupt the HBV life cycle in hepatocytes have been conducted. Potential treatment strategies and new agents are emerging as HBV cure. A combination of current and new anti-HBV agents may increase the rate of HBsAg seroclearance; thus, optimized regimens must be validated. Here, we review the newly investigated therapeutic compounds and the results of preclinical and/or clinical trials.https://www.mdpi.com/1422-0067/22/1/213hepatitis Btreatmentcuretarget |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hye Won Lee Jae Seung Lee Sang Hoon Ahn |
spellingShingle |
Hye Won Lee Jae Seung Lee Sang Hoon Ahn Hepatitis B Virus Cure: Targets and Future Therapies International Journal of Molecular Sciences hepatitis B treatment cure target |
author_facet |
Hye Won Lee Jae Seung Lee Sang Hoon Ahn |
author_sort |
Hye Won Lee |
title |
Hepatitis B Virus Cure: Targets and Future Therapies |
title_short |
Hepatitis B Virus Cure: Targets and Future Therapies |
title_full |
Hepatitis B Virus Cure: Targets and Future Therapies |
title_fullStr |
Hepatitis B Virus Cure: Targets and Future Therapies |
title_full_unstemmed |
Hepatitis B Virus Cure: Targets and Future Therapies |
title_sort |
hepatitis b virus cure: targets and future therapies |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-12-01 |
description |
Chronic hepatitis B virus (HBV) infection is a major global health problem. It can cause progressive liver fibrosis leading to cirrhosis with end-stage liver disease, and a markedly increased risk of hepatocellular carcinoma. In the last two decades, substantial progress has been made in the treatment of chronic hepatitis, B. However, HBV is often reactivated after stopping nucloes(t)ide analogues because antivirals alone do not directly target covalently closed circular DNA, which is the template for all viral RNAs. Therefore, although currently available antiviral therapies achieve suppression of HBV replication in the majority of patients, hepatitis B surface antigen (HBsAg) loss and seroconversion is rarely achieved despite long-term antiviral treatment (HBsAg loss of less than 10% in 5 years). Various clinical trials of agents that interrupt the HBV life cycle in hepatocytes have been conducted. Potential treatment strategies and new agents are emerging as HBV cure. A combination of current and new anti-HBV agents may increase the rate of HBsAg seroclearance; thus, optimized regimens must be validated. Here, we review the newly investigated therapeutic compounds and the results of preclinical and/or clinical trials. |
topic |
hepatitis B treatment cure target |
url |
https://www.mdpi.com/1422-0067/22/1/213 |
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