Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts.
The potential involvement of connective tissue growth factor (CCN2/CTGF) in extracellular matrix (ECM) production is recognized. However, the role CCN2 in fibronectin (FN) gene expression has remained incompletely understood and even controversial. Here we report that CCN2 is absolutely necessary fo...
Main Authors: | Trupta Purohit, Zhaoping Qin, Chunji Quan, Zhenhua Lin, Taihao Quan |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5340390?pdf=render |
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