Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

Summary: The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To better understand how HTT mediates axonal transport and why this function is disrupted in Huntington’s disease (HD), we study vesicl...

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Bibliographic Details
Main Authors: Alice Migazzi, Chiara Scaramuzzino, Eric N. Anderson, Debasmita Tripathy, Ivó H. Hernández, Rogan A. Grant, Michela Roccuzzo, Laura Tosatto, Amandine Virlogeux, Chiara Zuccato, Andrea Caricasole, Tamara Ratovitski, Christopher A. Ross, Udai B. Pandey, José J. Lucas, Frédéric Saudou, Maria Pennuto, Manuela Basso
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
huntingtin
Huntington’s disease
axonal transport
arginine methylation
PRMT6
protein post-translational modification
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002941

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