Ethnic variations in diabetes and prediabetes prevalence and the roles of insulin resistance and β-cell function: The CARRS and NHANES studies
Aims: It is unclear how the prevalence of diabetes in Asian Indians in urban India compares to that of race/ethnic groups in the US that may have different underlying susceptibilities. Therefore, we examined ethnic variations in the prevalence of type 2 diabetes, iIFG, iIGT, IFG + IGT, and the assoc...
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doaj-4ec775145ade417bb785b6bad9e105632020-11-24T23:59:33ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372016-06-014C192710.1016/j.jcte.2016.02.004Ethnic variations in diabetes and prediabetes prevalence and the roles of insulin resistance and β-cell function: The CARRS and NHANES studiesU.P. Gujral0V. Mohan1R. Pradeepa2M. Deepa3R.M. Anjana4N.K. Mehta5E.W. Gregg6K.M. Narayan7Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USAMadras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, WHO Collaborating Centre for Non-communicable Diseases, Prevention & Control, IDF Centre of Education, Chennai, IndiaMadras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, WHO Collaborating Centre for Non-communicable Diseases, Prevention & Control, IDF Centre of Education, Chennai, IndiaMadras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, WHO Collaborating Centre for Non-communicable Diseases, Prevention & Control, IDF Centre of Education, Chennai, IndiaMadras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialties Centre, WHO Collaborating Centre for Non-communicable Diseases, Prevention & Control, IDF Centre of Education, Chennai, IndiaHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USADivision of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA, USAHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USAAims: It is unclear how the prevalence of diabetes in Asian Indians in urban India compares to that of race/ethnic groups in the US that may have different underlying susceptibilities. Therefore, we examined ethnic variations in the prevalence of type 2 diabetes, iIFG, iIGT, IFG + IGT, and the associated risk factors in Asian Indians in Chennai, India, and Whites, Blacks, and Hispanics in the United States. Methods: Cross-sectional analyses, using representative samples of 4867 Asian Indians aged 20–74 years from Chennai, India, in the Centre for Cardiometabolic Risk Reduction in South-Asia study (CARRS) (2010–2011) and 6512 US Whites, Blacks, and Hispanics aged 20–74 years from the National Health and Nutrition Examination Survey (NHANES) (2007–2012). Results: The age-adjusted prevalence of type 2 diabetes was highest in Asian Indians (men: 28.4, 95% CI: 25.9, 31.0; women: 30.6, 95% CI, 27.5, 33.9) and lowest in Caucasians (men: 12.2, 95% CI, 10.3, 14.4, women: 9.5, 95% CI, 7.9, 11.5). Asian Indians had the lowest prediabetes prevalence (men: 19.0, 95% CI, 17.2, 20.8; women: 27.2, 95% CI, 22.8, 32.1) and Caucasians had the highest (men; 46.5, 95% CI, 43.5, 49.6, women: 34.4, 95% CI, 31.7, 37.3). However, there were differences in prediabetes prevalence by gender and prediabetes state. The inclusion of HOMA-β in standardized polytomous logistic regression models resulted in a greater odds of diabetes in Blacks and Hispanics compared to Asian Indians. Conclusions: The high prevalence of diabetes in Asian Indians may be due to innate susceptibilities for β-cell dysfunction in this high risk population.http://www.sciencedirect.com/science/article/pii/S2214623716300023Type 2 diabetesEthnicityAsian Indian |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
U.P. Gujral V. Mohan R. Pradeepa M. Deepa R.M. Anjana N.K. Mehta E.W. Gregg K.M. Narayan |
spellingShingle |
U.P. Gujral V. Mohan R. Pradeepa M. Deepa R.M. Anjana N.K. Mehta E.W. Gregg K.M. Narayan Ethnic variations in diabetes and prediabetes prevalence and the roles of insulin resistance and β-cell function: The CARRS and NHANES studies Journal of Clinical & Translational Endocrinology Type 2 diabetes Ethnicity Asian Indian |
author_facet |
U.P. Gujral V. Mohan R. Pradeepa M. Deepa R.M. Anjana N.K. Mehta E.W. Gregg K.M. Narayan |
author_sort |
U.P. Gujral |
title |
Ethnic variations in diabetes and prediabetes prevalence and the roles of insulin resistance and β-cell function: The CARRS and NHANES studies |
title_short |
Ethnic variations in diabetes and prediabetes prevalence and the roles of insulin resistance and β-cell function: The CARRS and NHANES studies |
title_full |
Ethnic variations in diabetes and prediabetes prevalence and the roles of insulin resistance and β-cell function: The CARRS and NHANES studies |
title_fullStr |
Ethnic variations in diabetes and prediabetes prevalence and the roles of insulin resistance and β-cell function: The CARRS and NHANES studies |
title_full_unstemmed |
Ethnic variations in diabetes and prediabetes prevalence and the roles of insulin resistance and β-cell function: The CARRS and NHANES studies |
title_sort |
ethnic variations in diabetes and prediabetes prevalence and the roles of insulin resistance and β-cell function: the carrs and nhanes studies |
publisher |
Elsevier |
series |
Journal of Clinical & Translational Endocrinology |
issn |
2214-6237 |
publishDate |
2016-06-01 |
description |
Aims: It is unclear how the prevalence of diabetes in Asian Indians in urban India compares to that of race/ethnic groups in the US that may have different underlying susceptibilities. Therefore, we examined ethnic variations in the prevalence of type 2 diabetes, iIFG, iIGT, IFG + IGT, and the associated risk factors in Asian Indians in Chennai, India, and Whites, Blacks, and Hispanics in the United States.
Methods: Cross-sectional analyses, using representative samples of 4867 Asian Indians aged 20–74 years from Chennai, India, in the Centre for Cardiometabolic Risk Reduction in South-Asia study (CARRS) (2010–2011) and 6512 US Whites, Blacks, and Hispanics aged 20–74 years from the National Health and Nutrition Examination Survey (NHANES) (2007–2012).
Results: The age-adjusted prevalence of type 2 diabetes was highest in Asian Indians (men: 28.4, 95% CI: 25.9, 31.0; women: 30.6, 95% CI, 27.5, 33.9) and lowest in Caucasians (men: 12.2, 95% CI, 10.3, 14.4, women: 9.5, 95% CI, 7.9, 11.5). Asian Indians had the lowest prediabetes prevalence (men: 19.0, 95% CI, 17.2, 20.8; women: 27.2, 95% CI, 22.8, 32.1) and Caucasians had the highest (men; 46.5, 95% CI, 43.5, 49.6, women: 34.4, 95% CI, 31.7, 37.3). However, there were differences in prediabetes prevalence by gender and prediabetes state. The inclusion of HOMA-β in standardized polytomous logistic regression models resulted in a greater odds of diabetes in Blacks and Hispanics compared to Asian Indians.
Conclusions: The high prevalence of diabetes in Asian Indians may be due to innate susceptibilities for β-cell dysfunction in this high risk population. |
topic |
Type 2 diabetes Ethnicity Asian Indian |
url |
http://www.sciencedirect.com/science/article/pii/S2214623716300023 |
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