Cellular proteostasis decline in human senescence

Cellular proteostasis decline in human senescence

A huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. The reduced ability of senescent cells to maintain protein homeostasis (proteostasis) has been well-established in nematodes but th...

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Main Author: Karli Montague-Cardoso
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01578-w
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spelling doaj-4ed7778eb2394cd581761c3fe019dc2a2021-01-10T12:41:41ZengNature Publishing GroupCommunications Biology2399-36422021-01-01411210.1038/s42003-020-01578-wCellular proteostasis decline in human senescenceKarli Montague-Cardoso0Communications BiologyA huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. The reduced ability of senescent cells to maintain protein homeostasis (proteostasis) has been well-established in nematodes but this phenomenon had yet to be directly demonstrated in human cells. Sabath et al. recently provided compelling evidence that proteostasis collapse is indeed intrinsic to human cell senescence, which may have broad implications in the underlying processes of human aging.https://doi.org/10.1038/s42003-020-01578-w
collection DOAJ
language English
format Article
sources DOAJ
author Karli Montague-Cardoso
spellingShingle Karli Montague-Cardoso
Cellular proteostasis decline in human senescence
Communications Biology
author_facet Karli Montague-Cardoso
author_sort Karli Montague-Cardoso
title Cellular proteostasis decline in human senescence
title_short Cellular proteostasis decline in human senescence
title_full Cellular proteostasis decline in human senescence
title_fullStr Cellular proteostasis decline in human senescence
title_full_unstemmed Cellular proteostasis decline in human senescence
title_sort cellular proteostasis decline in human senescence
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-01-01
description A huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. The reduced ability of senescent cells to maintain protein homeostasis (proteostasis) has been well-established in nematodes but this phenomenon had yet to be directly demonstrated in human cells. Sabath et al. recently provided compelling evidence that proteostasis collapse is indeed intrinsic to human cell senescence, which may have broad implications in the underlying processes of human aging.
url https://doi.org/10.1038/s42003-020-01578-w
work_keys_str_mv AT karlimontaguecardoso cellularproteostasisdeclineinhumansenescence
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