Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE
How transposable elements (TE) contribute to cell fate changes is unclear. Here, the authors generate a pipeline to quantify TE expression from single cell data. They show the dynamic expression of TEs from gastrulation to somatic cell reprogramming and human disease
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| Format: | Article |
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Nature Publishing Group
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21808-x |
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doaj-4ed9c74b80c94fd98b07d31c04585b6c2021-03-11T11:32:11ZengNature Publishing GroupNature Communications2041-17232021-03-0112111410.1038/s41467-021-21808-xIdentifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTEJiangping He0Isaac A. Babarinde1Li Sun2Shuyang Xu3Ruhai Chen4Junjie Shi5Yuanjie Wei6Yuhao Li7Gang Ma8Qiang Zhuang9Andrew P. Hutchins10Jiekai Chen11Center for Cell Lineage and Atlas (CCLA), Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)Department of Biology, Southern University of Science and TechnologyDepartment of Biology, Southern University of Science and TechnologyKey Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesKey Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesKey Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCenter for Cell Lineage and Atlas (CCLA), Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)Department of Biology, Southern University of Science and TechnologyDepartment of Biology, Southern University of Science and TechnologyDepartment of Biology, Southern University of Science and TechnologyDepartment of Biology, Southern University of Science and TechnologyCenter for Cell Lineage and Atlas (CCLA), Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory)How transposable elements (TE) contribute to cell fate changes is unclear. Here, the authors generate a pipeline to quantify TE expression from single cell data. They show the dynamic expression of TEs from gastrulation to somatic cell reprogramming and human diseasehttps://doi.org/10.1038/s41467-021-21808-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jiangping He Isaac A. Babarinde Li Sun Shuyang Xu Ruhai Chen Junjie Shi Yuanjie Wei Yuhao Li Gang Ma Qiang Zhuang Andrew P. Hutchins Jiekai Chen |
| spellingShingle |
Jiangping He Isaac A. Babarinde Li Sun Shuyang Xu Ruhai Chen Junjie Shi Yuanjie Wei Yuhao Li Gang Ma Qiang Zhuang Andrew P. Hutchins Jiekai Chen Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE Nature Communications |
| author_facet |
Jiangping He Isaac A. Babarinde Li Sun Shuyang Xu Ruhai Chen Junjie Shi Yuanjie Wei Yuhao Li Gang Ma Qiang Zhuang Andrew P. Hutchins Jiekai Chen |
| author_sort |
Jiangping He |
| title |
Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE |
| title_short |
Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE |
| title_full |
Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE |
| title_fullStr |
Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE |
| title_full_unstemmed |
Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE |
| title_sort |
identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scte |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-03-01 |
| description |
How transposable elements (TE) contribute to cell fate changes is unclear. Here, the authors generate a pipeline to quantify TE expression from single cell data. They show the dynamic expression of TEs from gastrulation to somatic cell reprogramming and human disease |
| url |
https://doi.org/10.1038/s41467-021-21808-x |
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