Prognostic significance of smac/DIABLO in endometrioid endometrial cancer
Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrialpathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examinedsmac/DIABLO expression in 76 patients with endometrioid endometrial cancers....
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Via Medica
2010-04-01
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Series: | Folia Histochemica et Cytobiologica |
Subjects: | |
Online Access: | http://www.fhc.viamedica.pl/darmowy_pdf.phtml?indeks=128&indeks_art=1292 |
Summary: | Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrialpathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examinedsmac/DIABLO expression in 76 patients with endometrioid endometrial cancers. Presence of smac/DIABLO was quantifiedby Western blot analysis using nonfixed fresh frozen tissues. Its appearance was found in 55 (72%) of examined tumors.Smac/DIABLO expression significantly correlated with tumor grade (p<0.001). Patients with positive smac/DIABLOtumors had a longer disease-specific survival when compared with those with negative tumors in the 10-year follow-up(p=0.043). The study demonstrated that negative smac/DIABLO expression was a poor prognostic sign. |
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ISSN: | 0239-8508 1897-5631 |