Cardia Gastric Cancer Is Associated With Increased PIK3CA Amplifications and HER2 Expression Than Noncardia Gastric Cancer According to Lauren Classification
BackgroundTo date, few reports have investigated genetic alterations and clinicopathological features in cardia and noncardia gastric cancer (GC).MethodsIn total, 435 GC patients receiving curative surgery were included. The clinicopathological features, recurrence patterns, prognoses and genetic al...
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doaj-4ee9d93cf9b54591bf5daa3022ea75c72021-06-08T05:14:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-06-011110.3389/fonc.2021.632609632609Cardia Gastric Cancer Is Associated With Increased PIK3CA Amplifications and HER2 Expression Than Noncardia Gastric Cancer According to Lauren ClassificationShih-Min Pai0Shih-Min Pai1Kuo-Hung Huang2Kuo-Hung Huang3Ming-Huang Chen4Ming-Huang Chen5Wen-Liang Fang6Wen-Liang Fang7Yee Chao8Yee Chao9Su-Shun Lo10Su-Shun Lo11Anna Fen-Yau Li12Anna Fen-Yau Li13Chew-Wun Wu14Chew-Wun Wu15Yi-Ming Shyr16Yi-Ming Shyr17Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCenter of Immuno-Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, TaiwanDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanCenter of Immuno-Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Surgery, National Yang Ming Chiao Tung University Hospital, Yilan, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDepartment of Pathology, Taipei Veterans General Hospital, Taipei, TaiwanDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, TaiwanSchool of Medicine, National Yang Ming Chiao Tung University, Taipei, TaiwanBackgroundTo date, few reports have investigated genetic alterations and clinicopathological features in cardia and noncardia gastric cancer (GC).MethodsIn total, 435 GC patients receiving curative surgery were included. The clinicopathological features, recurrence patterns, prognoses and genetic alterations were compared between cardia and noncardia GC patients.ResultsAmong the 435 enrolled patients, 47 (10.8%) had cardia GC. Compared with noncardia GC, cardia GC was associated with more intestinal-type tumors and similar initial recurrence patterns and 5-year overall survival (OS; 50.8% vs. 50.5%, P = 0.480) and disease-free survival (DFS; 48.6% vs. 48.9%, P = 0.392) rates. For both intestinal-type GC and diffuse-type GC, the clinicopathological features and 5-year OS and DFS rates were not significantly different between the cardia and noncardia GC patients. Multivariable analysis showed that cardia GC was not an independent prognostic factor. Compared with noncardia GC, cardia GC was associated with increased PIK3CA amplification than in patients with intestinal-type GC and was associated with increased HER2 expression in patients with diffuse-type GC.ConclusionsCardia GC is not an independent prognostic factor. In cardia GC patients with intestinal-type GC, PIK3CA amplification was more common, and in those with diffuse-type GC, HER2 expression was more common. Targeted therapy may be beneficial for these patient subgroups.https://www.frontiersin.org/articles/10.3389/fonc.2021.632609/fullgastric cancercardianoncardiagenetic alterationPIK3CA amplificationHER2 expression |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shih-Min Pai Shih-Min Pai Kuo-Hung Huang Kuo-Hung Huang Ming-Huang Chen Ming-Huang Chen Wen-Liang Fang Wen-Liang Fang Yee Chao Yee Chao Su-Shun Lo Su-Shun Lo Anna Fen-Yau Li Anna Fen-Yau Li Chew-Wun Wu Chew-Wun Wu Yi-Ming Shyr Yi-Ming Shyr |
spellingShingle |
Shih-Min Pai Shih-Min Pai Kuo-Hung Huang Kuo-Hung Huang Ming-Huang Chen Ming-Huang Chen Wen-Liang Fang Wen-Liang Fang Yee Chao Yee Chao Su-Shun Lo Su-Shun Lo Anna Fen-Yau Li Anna Fen-Yau Li Chew-Wun Wu Chew-Wun Wu Yi-Ming Shyr Yi-Ming Shyr Cardia Gastric Cancer Is Associated With Increased PIK3CA Amplifications and HER2 Expression Than Noncardia Gastric Cancer According to Lauren Classification Frontiers in Oncology gastric cancer cardia noncardia genetic alteration PIK3CA amplification HER2 expression |
author_facet |
Shih-Min Pai Shih-Min Pai Kuo-Hung Huang Kuo-Hung Huang Ming-Huang Chen Ming-Huang Chen Wen-Liang Fang Wen-Liang Fang Yee Chao Yee Chao Su-Shun Lo Su-Shun Lo Anna Fen-Yau Li Anna Fen-Yau Li Chew-Wun Wu Chew-Wun Wu Yi-Ming Shyr Yi-Ming Shyr |
author_sort |
Shih-Min Pai |
title |
Cardia Gastric Cancer Is Associated With Increased PIK3CA Amplifications and HER2 Expression Than Noncardia Gastric Cancer According to Lauren Classification |
title_short |
Cardia Gastric Cancer Is Associated With Increased PIK3CA Amplifications and HER2 Expression Than Noncardia Gastric Cancer According to Lauren Classification |
title_full |
Cardia Gastric Cancer Is Associated With Increased PIK3CA Amplifications and HER2 Expression Than Noncardia Gastric Cancer According to Lauren Classification |
title_fullStr |
Cardia Gastric Cancer Is Associated With Increased PIK3CA Amplifications and HER2 Expression Than Noncardia Gastric Cancer According to Lauren Classification |
title_full_unstemmed |
Cardia Gastric Cancer Is Associated With Increased PIK3CA Amplifications and HER2 Expression Than Noncardia Gastric Cancer According to Lauren Classification |
title_sort |
cardia gastric cancer is associated with increased pik3ca amplifications and her2 expression than noncardia gastric cancer according to lauren classification |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-06-01 |
description |
BackgroundTo date, few reports have investigated genetic alterations and clinicopathological features in cardia and noncardia gastric cancer (GC).MethodsIn total, 435 GC patients receiving curative surgery were included. The clinicopathological features, recurrence patterns, prognoses and genetic alterations were compared between cardia and noncardia GC patients.ResultsAmong the 435 enrolled patients, 47 (10.8%) had cardia GC. Compared with noncardia GC, cardia GC was associated with more intestinal-type tumors and similar initial recurrence patterns and 5-year overall survival (OS; 50.8% vs. 50.5%, P = 0.480) and disease-free survival (DFS; 48.6% vs. 48.9%, P = 0.392) rates. For both intestinal-type GC and diffuse-type GC, the clinicopathological features and 5-year OS and DFS rates were not significantly different between the cardia and noncardia GC patients. Multivariable analysis showed that cardia GC was not an independent prognostic factor. Compared with noncardia GC, cardia GC was associated with increased PIK3CA amplification than in patients with intestinal-type GC and was associated with increased HER2 expression in patients with diffuse-type GC.ConclusionsCardia GC is not an independent prognostic factor. In cardia GC patients with intestinal-type GC, PIK3CA amplification was more common, and in those with diffuse-type GC, HER2 expression was more common. Targeted therapy may be beneficial for these patient subgroups. |
topic |
gastric cancer cardia noncardia genetic alteration PIK3CA amplification HER2 expression |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.632609/full |
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